論文 - 詳細
| RRC ID | 58245 |
|---|---|
| 著者 | Hiraki-Kajiyama T, Yamashita J, Yokoyama K, Kikuchi Y, Nakajo M, Miyazoe D, Nishiike Y, Ishikawa K, Hosono K, Kawabata-Sakata Y, Ansai S, Kinoshita M, Nagahama Y, Okubo K. |
| タイトル | Neuropeptide B mediates female sexual receptivity in medaka fish, acting in a female-specific but reversible manner. |
| ジャーナル | Elife |
| Abstract |
Male and female animals display innate sex-specific mating behaviors. In teleost fish, altering the adult sex steroid milieu can effectively reverse sex-typical mating behaviors, suggesting remarkable sexual lability of their brains as adults. In the teleost medaka, neuropeptide B (NPB) is expressed female-specifically in the brain nuclei implicated in mating behavior. Here, we demonstrate that NPB is a direct mediator of estrogen action on female mating behavior, acting in a female-specific but reversible manner. Analysis of regulatory mechanisms revealed that the female-specific expression of NPB is dependent on direct transcriptional activation by estrogen via an estrogen-responsive element and is reversed in response to changes in the adult sex steroid milieu. Behavioral studies of NPB knockouts revealed that female-specific NBP mediates female receptivity to male courtship. The female-specific NPB signaling identified herein is presumably a critical element of the neural circuitry underlying sexual dimorphism and lability of mating behaviors in teleosts. |
| 巻・号 | 8 |
| 公開日 | 2019-8-6 |
| DOI | 10.7554/eLife.39495 |
| PII | 39495 |
| PMID | 31383257 |
| PMC | PMC6684226 |
| MeSH | Animals Estrogens / metabolism Female Gene Expression Regulation / drug effects Neuropeptides / metabolism* Oryzias / physiology* Sexual Behavior, Animal / drug effects* |
| IF | 7.08 |
| 引用数 | 2 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| メダカ | d-rR/TOKYO (MT837) BAC clone (ola1-180I09) d-rR-Tg(npba-GFP)2 (TG962) |