論文 - 詳細
| RRC ID | 58324 |
|---|---|
| 著者 | Yang X, Liang J, Ding L, Li X, Lam SM, Shui G, Ding M, Huang X. |
| タイトル | Phosphatidylserine synthase regulates cellular homeostasis through distinct metabolic mechanisms. |
| ジャーナル | PLoS Genet |
| Abstract |
Phosphatidylserine (PS), synthesized in the endoplasmic reticulum (ER) by phosphatidylserine synthase (PSS), is transported to the plasma membrane (PM) and mitochondria through distinct routes. The in vivo functions of PS at different subcellular locations and the coordination between different PS transport routes are not fully understood. Here, we report that Drosophila PSS regulates cell growth, lipid storage and mitochondrial function. In pss RNAi, reduced PS depletes plasma membrane Akt, contributing to cell growth defects; the metabolic shift from phospholipid synthesis to neutral lipid synthesis results in ectopic lipid accumulation; and the reduction of mitochondrial PS impairs mitochondrial protein import and mitochondrial integrity. Importantly, reducing PS transport from the ER to PM by loss of PI4KIIIα partially rescues the mitochondrial defects of pss RNAi. Together, our results uncover a balance between different PS transport routes and reveal that PSS regulates cellular homeostasis through distinct metabolic mechanisms. |
| 巻・号 | 15(12) |
| ページ | e1008548 |
| 公開日 | 2019-12-1 |
| DOI | 10.1371/journal.pgen.1008548 |
| PII | PGENETICS-D-19-00778 |
| PMID | 31869331 |
| PMC | PMC6946173 |
| MeSH | Animals CDP-Diacylglycerol-Inositol 3-Phosphatidyltransferase / metabolism* CDPdiacylglycerol-Serine O-Phosphatidyltransferase / metabolism* Cell Membrane / metabolism* Drosophila Proteins / metabolism* Drosophila melanogaster / metabolism* Endoplasmic Reticulum / metabolism* Homeostasis Mitochondria / metabolism Phosphatidylserines / metabolism* Protein Transport Proto-Oncogene Proteins c-akt / metabolism |
| IF | 5.175 |
| 引用数 | 3 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 4825R-1 4825R-3 |