論文 - 詳細
| RRC ID | 58456 |
|---|---|
| 著者 | Cordeiro IR, Kabashima K, Ochi H, Munakata K, Nishimori C, Laslo M, Hanken J, Tanaka M. |
| タイトル | Environmental Oxygen Exposure Allows for the Evolution of Interdigital Cell Death in Limb Patterning. |
| ジャーナル | Dev Cell |
| Abstract |
Amphibians form fingers without webbing by differential growth between digital and interdigital regions. Amniotes, however, employ interdigital cell death (ICD), an additional mechanism that contributes to a greater variation of limb shapes. Here, we investigate the role of environmental oxygen in the evolution of ICD in tetrapods. While cell death is restricted to the limb margin in amphibians with aquatic tadpoles, Eleutherodactylus coqui, a frog with terrestrial-direct-developing eggs, has cell death in the interdigital region. Chicken requires sufficient oxygen and reactive oxygen species to induce cell death, with the oxygen tension profile itself being distinct between the limbs of chicken and Xenopus laevis frogs. Notably, increasing blood vessel density in X. laevis limbs, as well as incubating tadpoles under high oxygen levels, induces ICD. We propose that the oxygen available to terrestrial eggs was an ecological feature crucial for the evolution of ICD, made possible by conserved autopod-patterning mechanisms. |
| 巻・号 | 50(2) |
| ページ | 155-166.e4 |
| 公開日 | 2019-7-22 |
| DOI | 10.1016/j.devcel.2019.05.025 |
| PII | S1534-5807(19)30423-X |
| PMID | 31204171 |
| MeSH | Animals Body Patterning* Bone Morphogenetic Proteins / genetics Bone Morphogenetic Proteins / metabolism Cell Death* / drug effects Chick Embryo Extremities / blood supply* Extremities / pathology* Larva / drug effects Larva / growth & development* Morphogenesis* Oxygen / pharmacology* Reactive Oxygen Species / metabolism Xenopus laevis |
| IF | 10.092 |
| 引用数 | 1 |
| オルトメトリクス指標 |
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 40 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ツメガエル・イモリ | |