RRC ID 58456
Author Cordeiro IR, Kabashima K, Ochi H, Munakata K, Nishimori C, Laslo M, Hanken J, Tanaka M.
Title Environmental Oxygen Exposure Allows for the Evolution of Interdigital Cell Death in Limb Patterning.
Journal Dev Cell
Abstract Amphibians form fingers without webbing by differential growth between digital and interdigital regions. Amniotes, however, employ interdigital cell death (ICD), an additional mechanism that contributes to a greater variation of limb shapes. Here, we investigate the role of environmental oxygen in the evolution of ICD in tetrapods. While cell death is restricted to the limb margin in amphibians with aquatic tadpoles, Eleutherodactylus coqui, a frog with terrestrial-direct-developing eggs, has cell death in the interdigital region. Chicken requires sufficient oxygen and reactive oxygen species to induce cell death, with the oxygen tension profile itself being distinct between the limbs of chicken and Xenopus laevis frogs. Notably, increasing blood vessel density in X. laevis limbs, as well as incubating tadpoles under high oxygen levels, induces ICD. We propose that the oxygen available to terrestrial eggs was an ecological feature crucial for the evolution of ICD, made possible by conserved autopod-patterning mechanisms.
Volume 50(2)
Pages 155-166.e4
Published 2019-7-22
DOI 10.1016/j.devcel.2019.05.025
PII S1534-5807(19)30423-X
PMID 31204171
MeSH Animals Body Patterning* Bone Morphogenetic Proteins / genetics Bone Morphogenetic Proteins / metabolism Cell Death* / drug effects Chick Embryo Extremities / blood supply* Extremities / pathology* Larva / drug effects Larva / growth & development* Morphogenesis* Oxygen / pharmacology* Reactive Oxygen Species / metabolism Xenopus laevis
IF 10.092
Times Cited 1
Clawed frogs / Newts