論文 - 詳細
| RRC ID | 58487 |
|---|---|
| 著者 | Tang H, Serada S, Kawabata A, Ota M, Hayashi E, Naka T, Yamanishi K, Mori Y. |
| タイトル | CD134 is a cellular receptor specific for human herpesvirus-6B entry. |
| ジャーナル | Proc Natl Acad Sci U S A |
| Abstract |
Human herpesvirus-6B (HHV-6B) is a T lymphotropic β-herpesvirus that is clearly distinct from human herpesvirus-6A (HHV-6A) according to molecular biological features. The International Committee on Taxonomy of Viruses recently classified HHV-6B as a separate species. The primary HHV-6B infection causes exanthem subitum and is sometimes associated with severe encephalopathy. More than 90% of the general population is infected with HHV-6B during childhood, and the virus remains throughout life as a latent infection. HHV-6B reactivation causes encephalitis in immunosuppressed patients. The cellular receptor for HHV-6A entry was identified as human CD46, but the receptor for HHV-6B has not been clear. Here we found that CD134, a member of the TNF receptor superfamily, functions as a specific entry receptor for HHV-6B. A T-cell line that is normally nonpermissive for HHV-6B infection became highly susceptible to infection when CD134 was overexpressed. CD134 was down-regulated in HHV-6B-infected T cells. Soluble CD134 interacted with the HHV-6B glycoprotein complex that serves as a viral ligand for cellular receptor, which inhibited HHV-6B but not HHV-6A infection in target cells. The identification of CD134 as an HHV-6B specific entry receptor provides important insight into understanding HHV-6B entry and its pathogenesis. |
| 巻・号 | 110(22) |
| ページ | 9096-9 |
| 公開日 | 2013-5-28 |
| DOI | 10.1073/pnas.1305187110 |
| PII | 1305187110 |
| PMID | 23674671 |
| PMC | PMC3670305 |
| MeSH | Flow Cytometry HEK293 Cells Herpesvirus 6, Human / metabolism Herpesvirus 6, Human / physiology* Humans Plasmids / genetics Receptors, OX40 / metabolism* T-Lymphocytes / metabolism T-Lymphocytes / virology Viral Fusion Proteins / metabolism* Virus Internalization* |
| IF | 9.412 |
| 引用数 | 71 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 各媒体での言及数の合計 | 0 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 遺伝子材料 | CS-CA-MCS (RDB05963) |
| 研究用ヒト臍帯血幹細胞 | |