RRC ID 58487
Author Tang H, Serada S, Kawabata A, Ota M, Hayashi E, Naka T, Yamanishi K, Mori Y.
Title CD134 is a cellular receptor specific for human herpesvirus-6B entry.
Journal Proc Natl Acad Sci U S A
Abstract Human herpesvirus-6B (HHV-6B) is a T lymphotropic β-herpesvirus that is clearly distinct from human herpesvirus-6A (HHV-6A) according to molecular biological features. The International Committee on Taxonomy of Viruses recently classified HHV-6B as a separate species. The primary HHV-6B infection causes exanthem subitum and is sometimes associated with severe encephalopathy. More than 90% of the general population is infected with HHV-6B during childhood, and the virus remains throughout life as a latent infection. HHV-6B reactivation causes encephalitis in immunosuppressed patients. The cellular receptor for HHV-6A entry was identified as human CD46, but the receptor for HHV-6B has not been clear. Here we found that CD134, a member of the TNF receptor superfamily, functions as a specific entry receptor for HHV-6B. A T-cell line that is normally nonpermissive for HHV-6B infection became highly susceptible to infection when CD134 was overexpressed. CD134 was down-regulated in HHV-6B-infected T cells. Soluble CD134 interacted with the HHV-6B glycoprotein complex that serves as a viral ligand for cellular receptor, which inhibited HHV-6B but not HHV-6A infection in target cells. The identification of CD134 as an HHV-6B specific entry receptor provides important insight into understanding HHV-6B entry and its pathogenesis.
Volume 110(22)
Pages 9096-9
Published 2013-5-28
DOI 10.1073/pnas.1305187110
PII 1305187110
PMID 23674671
PMC PMC3670305
MeSH Flow Cytometry HEK293 Cells Herpesvirus 6, Human / metabolism Herpesvirus 6, Human / physiology* Humans Plasmids / genetics Receptors, OX40 / metabolism* T-Lymphocytes / metabolism T-Lymphocytes / virology Viral Fusion Proteins / metabolism* Virus Internalization*
IF 9.412
Times Cited 71
DNA material CS-CA-MCS (RDB05963)