RRC ID 58613
著者 Weitzmann A, Naumann R, Dudeck A, Zerjatke T, Gerbaulet A, Roers A.
タイトル Mast Cells Occupy Stable Clonal Territories in Adult Steady-State Skin.
ジャーナル J Invest Dermatol
Abstract Mast cells (MCs) are tissue-resident hematopoietic cells intensely studied for their role as effectors in allergic immune responses. Yolk sac-derived embryonic MCs first populate tissues and are later replaced by definitive MCs. We show that definitive MC progenitors expand locally in skin and form clonal colonies that cover stable territories. In MC-deficient skin, colonies grow by proliferation of MCs at the border of the clonal territory. Clonal growth ceases at common borders of neighboring colonies. In steady state, colony self-renewal is independent of bone marrow contribution, and the clonal architecture remains fixed if not disturbed by skin inflammation. Inflammatory cues increase MC density setpoint, stimulating the influx of new progenitors from the bone marrow as well as proliferation of skin-resident cells. The expanding new arrivals disrespect territories of preexisting MC clones. We conclude that during a limited window early in development, definitive MC precursors efficiently enter the skin, expand, and self-maintain, occupying stable territories. In adulthood, circulating progenitors, excluded from steady-state skin, are recruited only into inflamed skin where they clonally expand alongside proliferating skin-resident MCs, disorganizing the original architecture of clonal territories.
巻・号 140(12)
ページ 2433-2441.e5
公開日 2020-12-1
DOI 10.1016/j.jid.2020.03.963
PII S0022-202X(20)31380-4
PMID 32311397
MeSH Adult Stem Cells / physiology* Animals Bone Marrow Cell Self Renewal / immunology* Cells, Cultured Dermatitis / immunology* Dermatitis / pathology Disease Models, Animal Embryo, Mammalian Embryonic Stem Cells / physiology Female Humans Male Mast Cells / immunology* Mice Mice, Transgenic Morula / cytology Skin / cytology Skin / immunology Skin / pathology* Tetradecanoylphorbol Acetate / immunology
IF 6.29
リソース情報
実験動物マウス RBRC02705