論文 - 詳細
| RRC ID | 58632 |
|---|---|
| 著者 | Hitora Y, Takada K, Ise Y, Woo SP, Inoue S, Mori N, Takikawa H, Nakamukai S, Okada S, Matsunaga S. |
| タイトル | Metachromins X and Y from a marine sponge Spongia sp. and their effects on cell cycle progression. |
| ジャーナル | Bioorg Med Chem |
| Abstract |
New sesquiterpene quinones, metachromins X (1) and Y (2), together with the known metachromins C (3), J (4), and T (5), were isolated as inhibitors of cell cycle progression in the HeLa/Fucci2 cells. The structure of 1 was assigned by spectroscopic data and confirmed by a total synthesis. The planar structure of 2 was determined by interpretation of spectroscopic data, whereas its absolute configuration was analyzed by a combination of chiral HPLC and CD spectroscopy. Metachromins X (1) and C (3) arrested the cell cycle progression of HeLa/Fucci2 cells at S/G2/M phase. |
| 巻・号 | 28(2) |
| ページ | 115233 |
| 公開日 | 2020-1-15 |
| DOI | 10.1016/j.bmc.2019.115233 |
| PII | S0968-0896(19)31782-1 |
| PMID | 31848114 |
| MeSH | Animals Antineoplastic Agents / chemistry Antineoplastic Agents / isolation & purification Antineoplastic Agents / pharmacology* Cell Cycle / drug effects Cell Proliferation / drug effects Dose-Response Relationship, Drug Drug Screening Assays, Antitumor HeLa Cells Humans Molecular Structure Porifera / chemistry* Sesquiterpenes / chemistry Sesquiterpenes / isolation & purification Sesquiterpenes / pharmacology* Structure-Activity Relationship Tumor Cells, Cultured |
| IF | 3.073 |
| 引用数 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | HeLa/Fucci2(RCB2867) |