論文 - 詳細
| RRC ID | 58635 |
|---|---|
| 著者 | Iijima Y, Bandow K, Sano M, Hino S, Kaneko T, Horie N, Sakagami H. |
| タイトル | In Vitro Assessment of Antitumor Potential and Combination Effect of Classical and Molecular-targeted Anticancer Drugs. |
| ジャーナル | Anticancer Res |
| Abstract |
BACKGROUND/AIM:The aim of the study was to evaluate the antitumor potential and combination effects of chemotherapeutic drugs. MATERIALS AND METHODS:The cytotoxicity of 20 drip-type classical and molecular-targeted anticancer drugs was examined against 4 human oral squamous cell carcinoma cell lines and 5 human oral normal mesenchymal and epithelial cells. Cell cycle progression was monitored by a cell sorter. Combination effect was evaluated by combination index. RESULTS:Most of the classical anticancer drugs showed much higher antitumor activity than molecular-targeted drugs, except bortezomib. Among 12 classical anticancer drugs, taxanes and gemsitabine showed the highest tumor-specificity (TS) and potency-selectivity expression (PSE) values, whereas platinum analogs showed the least TS value. Combination of two classical or a classical and a molecular-targeted drug showed mostly additive or antagonistic effect. 5-FU and cisplatin did not produce a subG1 population, but induced G2/M or G1/S arrest, regardless of the addition of cetuximab. Cetuximab, nibolumab and bortezomib showed potent keratinocyte toxicity. CONCLUSION:The present TS monitoring system may provide useful information for building up the treatment regimens of anticancer drugs. |
| 巻・号 | 39(12) |
| ページ | 6673-6684 |
| 公開日 | 2019-12-1 |
| DOI | 10.21873/anticanres.13882 |
| PII | 39/12/6673 |
| PMID | 31810932 |
| MeSH | Antineoplastic Agents / pharmacology* Antineoplastic Combined Chemotherapy Protocols / pharmacology* Bortezomib / pharmacology Carcinoma, Squamous Cell / drug therapy* Cell Cycle / drug effects Cell Line, Tumor Cetuximab / pharmacology Deoxycytidine / analogs & derivatives Deoxycytidine / pharmacology Drug Screening Assays, Antitumor Epithelial Cells / drug effects* Fibroblasts / drug effects Fluorouracil / pharmacology Gemcitabine Hormesis Humans In Vitro Techniques Keratinocytes / drug effects Molecular Targeted Therapy* Mouth Mucosa / cytology Mouth Neoplasms / drug therapy* Nivolumab / pharmacology Platinum Compounds / pharmacology Taxoids / pharmacology |
| IF | 1.994 |
| 引用数 | 3 |
| リソース情報 | |
| ヒト・動物細胞 | Ca9-22(RCB1976) HSC-2(RCB1945), HSC-3(RCB1975) HSC-4(RCB1902) |