論文 - 詳細
| RRC ID | 5867 |
|---|---|
| 著者 | Xiao JZ, Takahashi S, Nishimoto M, Odamaki T, Yaeshima T, Iwatsuki K, Kitaoka M. |
| タイトル | Distribution of in vitro fermentation ability of lacto-N-biose I, a major building block of human milk oligosaccharides, in bifidobacterial strains. |
| ジャーナル | Appl Environ Microbiol |
| Abstract |
This study investigated the potential utilization of lacto-N-biose I (LNB) by individual strains of bifidobacteria. LNB is a building block for the human milk oligosaccharides, which have been suggested to be a factor for selective growth of bifidobacteria. A total of 208 strains comprising 10 species and 4 subspecies were analyzed for the presence of the galacto-N-biose/lacto-N-biose I phosphorylase (GLNBP) gene (lnpA) and examined for growth when LNB was used as the sole carbohydrate source. While all strains of Bifidobacterium longum subsp. longum, B. longum subsp. infantis, B. breve, and B. bifidum were able to grow on LNB, none of the strains of B. adolescentis, B. catenulatum, B. dentium, B. angulatum, B. animalis subsp. lactis, and B. thermophilum showed any growth. In addition, some strains of B. pseudocatenulatum, B. animalis subsp. animalis, and B. pseudolongum exhibited the ability to utilize LNB. With the exception for B. pseudocatenulatum, the presence of lnpA coincided with LNB utilization in almost all strains. These results indicate that bifidobacterial species, which are the predominant species found in infant intestines, are potential utilizers of LNB. These findings support the hypothesis that GLNBP plays a key role in the colonization of bifidobacteria in the infant intestine. |
| 巻・号 | 76(1) |
| ページ | 54-9 |
| 公開日 | 2010-1-1 |
| DOI | 10.1128/AEM.01683-09 |
| PII | AEM.01683-09 |
| PMID | 19854932 |
| PMC | PMC2798660 |
| MeSH | Acetylglucosamine / analogs & derivatives* Acetylglucosamine / metabolism Bacterial Proteins / genetics Bifidobacterium / enzymology Bifidobacterium / genetics Bifidobacterium / growth & development Bifidobacterium / metabolism* Fermentation Humans Milk, Human / chemistry* Oligosaccharides / metabolism |
| IF | 4.016 |
| 引用数 | 71 |
| WOS 分野 | BIOTECHNOLOGY & APPLIED MICROBIOLOGY MICROBIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 34 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 3.0 |
| リソース情報 | |
| 一般微生物 | JCM 7130 JCM 7040 JCM 7135 JCM 1253 |