| RRC ID |
58693
|
| 著者 |
Ishiuchi K, Hirose D, Kondo T, Watanabe K, Terasaka K, Makino T.
|
| タイトル |
Mariannamides A and B, new cyclic octapeptides isolated from Mariannaea elegans NBRC102301.
|
| ジャーナル |
Bioorg Med Chem Lett
|
| Abstract |
Two new cyclic octapeptides, mariannamides A (1) and B (2), have been isolated from Mariannaea elegans NBRC102301, a Pinus densiflora-derived filamentous fungus. Their structures were elucidated to be cyclo-(l-Leu1-l-Pro1-l-Pro2-l-Leu2-l-Ile1-l-Pro3-l-Val1-l-Ile2) and cyclo-(l-Leu1-l-Pro1-l-Pro2-l-Leu2-l-Ile1-l-Pro3-l-Val1-l-Val2) based on spectroscopic data and Marfey's method. Mariannamide A (1) promoted mRNA expression of sirtuin 1 (SIRT1) in C2C12 cells, a mouse skeletal muscle myoblast cell line, and showed the antimicrobial activity against Escherichia coli and Cryptococcus neoformans.
|
| 巻・号 |
30(4)
|
| ページ |
126946
|
| 公開日 |
2020-2-15
|
| DOI |
10.1016/j.bmcl.2019.126946
|
| PII |
S0960-894X(19)30932-1
|
| PMID |
31928840
|
| MeSH |
Amino Acid Sequence
Animals
Bacteria / drug effects
Cell Line
Fungi / drug effects
Hypocreales / metabolism*
Magnetic Resonance Spectroscopy
Mass Spectrometry
Mice
Microbial Sensitivity Tests
Molecular Conformation
Oligopeptides / chemistry
Oligopeptides / isolation & purification
Oligopeptides / metabolism*
Oligopeptides / pharmacology
Peptides, Cyclic / chemistry
Peptides, Cyclic / isolation & purification
Peptides, Cyclic / metabolism*
Peptides, Cyclic / pharmacology
RNA, Messenger / metabolism
Sirtuin 1 / genetics
Sirtuin 1 / metabolism
Up-Regulation / drug effects
|
| IF |
2.572
|
| 引用数 |
0
|
| リソース情報 |
| ヒト・動物細胞 |
C2C12(RCB0987) |
| 一般微生物 |
JCM15448
JCM7783 |
