RRC ID 58693
Author Ishiuchi K, Hirose D, Kondo T, Watanabe K, Terasaka K, Makino T.
Title Mariannamides A and B, new cyclic octapeptides isolated from Mariannaea elegans NBRC102301.
Journal Bioorg Med Chem Lett
Abstract Two new cyclic octapeptides, mariannamides A (1) and B (2), have been isolated from Mariannaea elegans NBRC102301, a Pinus densiflora-derived filamentous fungus. Their structures were elucidated to be cyclo-(l-Leu1-l-Pro1-l-Pro2-l-Leu2-l-Ile1-l-Pro3-l-Val1-l-Ile2) and cyclo-(l-Leu1-l-Pro1-l-Pro2-l-Leu2-l-Ile1-l-Pro3-l-Val1-l-Val2) based on spectroscopic data and Marfey's method. Mariannamide A (1) promoted mRNA expression of sirtuin 1 (SIRT1) in C2C12 cells, a mouse skeletal muscle myoblast cell line, and showed the antimicrobial activity against Escherichia coli and Cryptococcus neoformans.
Volume 30(4)
Pages 126946
Published 2020-2-15
DOI 10.1016/j.bmcl.2019.126946
PII S0960-894X(19)30932-1
PMID 31928840
MeSH Amino Acid Sequence Animals Bacteria / drug effects Cell Line Fungi / drug effects Hypocreales / metabolism* Magnetic Resonance Spectroscopy Mass Spectrometry Mice Microbial Sensitivity Tests Molecular Conformation Oligopeptides / chemistry Oligopeptides / isolation & purification Oligopeptides / metabolism* Oligopeptides / pharmacology Peptides, Cyclic / chemistry Peptides, Cyclic / isolation & purification Peptides, Cyclic / metabolism* Peptides, Cyclic / pharmacology RNA, Messenger / metabolism Sirtuin 1 / genetics Sirtuin 1 / metabolism Up-Regulation / drug effects
IF 2.572
Times Cited 0
Human and Animal Cells C2C12(RCB0987)
General Microbes JCM15448 JCM7783