論文 - 詳細
| RRC ID | 58693 |
|---|---|
| 著者 | Ishiuchi K, Hirose D, Kondo T, Watanabe K, Terasaka K, Makino T. |
| タイトル | Mariannamides A and B, new cyclic octapeptides isolated from Mariannaea elegans NBRC102301. |
| ジャーナル | Bioorg Med Chem Lett |
| Abstract |
Two new cyclic octapeptides, mariannamides A (1) and B (2), have been isolated from Mariannaea elegans NBRC102301, a Pinus densiflora-derived filamentous fungus. Their structures were elucidated to be cyclo-(l-Leu1-l-Pro1-l-Pro2-l-Leu2-l-Ile1-l-Pro3-l-Val1-l-Ile2) and cyclo-(l-Leu1-l-Pro1-l-Pro2-l-Leu2-l-Ile1-l-Pro3-l-Val1-l-Val2) based on spectroscopic data and Marfey's method. Mariannamide A (1) promoted mRNA expression of sirtuin 1 (SIRT1) in C2C12 cells, a mouse skeletal muscle myoblast cell line, and showed the antimicrobial activity against Escherichia coli and Cryptococcus neoformans. |
| 巻・号 | 30(4) |
| ページ | 126946 |
| 公開日 | 2020-2-15 |
| DOI | 10.1016/j.bmcl.2019.126946 |
| PII | S0960-894X(19)30932-1 |
| PMID | 31928840 |
| MeSH | Amino Acid Sequence Animals Bacteria / drug effects Cell Line Fungi / drug effects Hypocreales / metabolism* Magnetic Resonance Spectroscopy Mass Spectrometry Mice Microbial Sensitivity Tests Molecular Conformation Oligopeptides / chemistry Oligopeptides / isolation & purification Oligopeptides / metabolism* Oligopeptides / pharmacology Peptides, Cyclic / chemistry Peptides, Cyclic / isolation & purification Peptides, Cyclic / metabolism* Peptides, Cyclic / pharmacology RNA, Messenger / metabolism Sirtuin 1 / genetics Sirtuin 1 / metabolism Up-Regulation / drug effects |
| IF | 2.572 |
| 引用数 | 0 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | C2C12(RCB0987) |
| 一般微生物 | JCM15448 JCM7783 |