| RRC ID |
58769
|
| 著者 |
Krishnan M, Hwang JS, Kim M, Kim YJ, Seo JH, Jung J, Ha E.
|
| タイトル |
β-hydroxybutyrate Impedes the Progression of Alzheimer's Disease and Atherosclerosis in ApoE-Deficient Mice.
|
| ジャーナル |
Nutrients
|
| Abstract |
β-hydroxybutyrate (β-OHB) has been shown to exert an anti-inflammatory activity. Apolipoprotein-E (ApoE) is strongly associated with atherosclerosis and Alzheimer's disease (AD). This study aimed to explore the therapeutic effect of β-OHB in the brain and the aorta of high-fat diet (HFD)-fed ApoE-deficient mice. We found in Apo-E deficient mice that β-OHB attenuated lipid deposition in the choroid plexus (ChP) and decreased amyloid plaque in the substantia nigra pars compacta. We also found decreased CD68-positive macroglia infiltration of the ChP in β-OHB-treated ApoE-deficient mice. β-OHB treatment ameliorated IgG extravasation into the hippocampal region of the brain. In vitro study using ChP mice cell line revealed that β-OHB attenuated oxidized low-density lipoprotein-induced ApoE-specific differentially expressed inflammatory ChP genes. Treatment with β-OHB reduced aortic plaque formation without affecting blood lipid profiles and decreased serum production of resistin, a well-established risk factor for both AD and atherosclerosis. Thus, the current study suggests and describes the therapeutic potential of β-OHB for the treatment of AD and atherosclerosis.
|
| 巻・号 |
12(2)
|
| 公開日 |
2020-2-13
|
| DOI |
10.3390/nu12020471
|
| PII |
nu12020471
|
| PMID |
32069870
|
| PMC |
PMC7071244
|
| MeSH |
3-Hydroxybutyric Acid / pharmacology*
Alzheimer Disease / drug therapy*
Alzheimer Disease / etiology
Animals
Anti-Inflammatory Agents / pharmacology*
Aorta / drug effects
Apolipoproteins E / deficiency
Atherosclerosis / drug therapy*
Atherosclerosis / etiology
Brain / drug effects
Diet, High-Fat
Disease Models, Animal
Disease Progression
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Plaque, Amyloid
|
| IF |
4.546
|
| 引用数 |
0
|
| リソース情報 |
| ヒト・動物細胞 |
ECPC-4(RCB1287) |
