| RRC ID |
58905
|
| 著者 |
Kagotani K, Nakayama H, Zang L, Fujimoto Y, Hayashi A, Sono R, Nishimura N, Shimada Y.
|
| タイトル |
Lecithin-Based Dermal Drug Delivery for Anti-Pigmentation Maize Ceramide.
|
| ジャーナル |
Molecules
|
| Abstract |
Ceramides have several well-known biological properties, including anti-pigmentation and anti-melanogenesis, which make them applicable for use in skincare products in cosmetics. However, the efficacy of ceramides is still limited. Dermal or transdermal drug delivery systems can enhance the anti-pigmentation properties of ceramides, although there is currently no systemic evaluation method for the efficacy of these systems. Here we prepared several types of lecithin-based emulsion of maize-derived glucosylceramide, determining PC70-ceramide (phosphatidylcholine-base) to be the safest and most effective anti-pigmentation agent using zebrafish larvae. We also demonstrated the efficacy of PC70 as a drug delivery system by showing that PC70-Nile Red (red fluorescence) promoted Nile Red accumulation in the larval bodies. In addition, PC70-ceramide suppressed melanin in mouse B16 melanoma cells compared to ceramide alone. In conclusion, we developed a lecithin-based dermal delivery method for ceramide using zebrafish larvae with implications for human clinical use.
|
| 巻・号 |
25(7)
|
| 公開日 |
2020-3-31
|
| DOI |
10.3390/molecules25071595
|
| PII |
molecules25071595
|
| PMID |
32244349
|
| PMC |
PMC7180834
|
| MeSH |
Animals
Ceramides / administration & dosage*
Ceramides / chemistry
Drug Carriers / chemistry*
Drug Delivery Systems*
Lecithins / chemistry*
Melanoma, Experimental
Mice
Pigmentation / drug effects*
Skin Pigmentation / drug effects
Zea mays / chemistry*
Zebrafish
|
| IF |
3.267
|
| 引用数 |
0
|
| リソース情報 |
| ヒト・動物細胞 |
B16 melanoma 4A5(RCB0557) |
