論文 - 詳細
| RRC ID | 58905 |
|---|---|
| 著者 | Kagotani K, Nakayama H, Zang L, Fujimoto Y, Hayashi A, Sono R, Nishimura N, Shimada Y. |
| タイトル | Lecithin-Based Dermal Drug Delivery for Anti-Pigmentation Maize Ceramide. |
| ジャーナル | Molecules |
| Abstract |
Ceramides have several well-known biological properties, including anti-pigmentation and anti-melanogenesis, which make them applicable for use in skincare products in cosmetics. However, the efficacy of ceramides is still limited. Dermal or transdermal drug delivery systems can enhance the anti-pigmentation properties of ceramides, although there is currently no systemic evaluation method for the efficacy of these systems. Here we prepared several types of lecithin-based emulsion of maize-derived glucosylceramide, determining PC70-ceramide (phosphatidylcholine-base) to be the safest and most effective anti-pigmentation agent using zebrafish larvae. We also demonstrated the efficacy of PC70 as a drug delivery system by showing that PC70-Nile Red (red fluorescence) promoted Nile Red accumulation in the larval bodies. In addition, PC70-ceramide suppressed melanin in mouse B16 melanoma cells compared to ceramide alone. In conclusion, we developed a lecithin-based dermal delivery method for ceramide using zebrafish larvae with implications for human clinical use. |
| 巻・号 | 25(7) |
| 公開日 | 2020-3-31 |
| DOI | 10.3390/molecules25071595 |
| PII | molecules25071595 |
| PMID | 32244349 |
| PMC | PMC7180834 |
| MeSH | Animals Ceramides / administration & dosage* Ceramides / chemistry Drug Carriers / chemistry* Drug Delivery Systems* Lecithins / chemistry* Melanoma, Experimental Mice Pigmentation / drug effects* Skin Pigmentation / drug effects Zea mays / chemistry* Zebrafish |
| IF | 3.267 |
| 引用数 | 0 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | B16 melanoma 4A5(RCB0557) |