論文 - 詳細
| RRC ID | 59116 |
|---|---|
| 著者 | Leung NY, Thakur DP, Gurav AS, Kim SH, Di Pizio A, Niv MY, Montell C. |
| タイトル | Functions of Opsins in Drosophila Taste. |
| ジャーナル | Curr Biol |
| Abstract |
Rhodopsin is a light receptor comprised of an opsin protein and a light-sensitive retinal chromophore. Despite more than a century of scrutiny, there is no evidence that opsins function in chemosensation. Here, we demonstrate that three Drosophila opsins, Rh1, Rh4, and Rh7, are needed in gustatory receptor neurons to sense a plant-derived bitter compound, aristolochic acid (ARI). The gustatory requirements for these opsins are light-independent and do not require retinal. The opsins enabled flies to detect lower concentrations of aristolochic acid by initiating an amplification cascade that includes a G-protein, phospholipase Cβ, and the TRP channel, TRPA1. In contrast, responses to higher levels of the bitter compound were mediated through direct activation of TRPA1. Our study reveals roles for opsins in chemosensation and raise questions concerning the original roles for these classical G-protein-coupled receptors. |
| 巻・号 | 30(8) |
| ページ | 1367-1379.e6 |
| 公開日 | 2020-4-20 |
| DOI | 10.1016/j.cub.2020.01.068 |
| PII | S0960-9822(20)30112-3 |
| PMID | 32243853 |
| PMC | PMC7252503 |
| MeSH | Animals Drosophila Proteins / genetics* Drosophila Proteins / metabolism Drosophila melanogaster / genetics Drosophila melanogaster / physiology* Female Male Opsins / genetics* Opsins / metabolism Random Allocation Taste / physiology* Taste Perception / physiology* |
| IF | 9.601 |
| 引用数 | 1 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 62 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#109600 |