論文 - 詳細
| RRC ID | 59117 |
|---|---|
| 著者 | Sato K, Ahsan MT, Ote M, Koganezawa M, Yamamoto D. |
| タイトル | Calmodulin-binding transcription factor shapes the male courtship song in Drosophila. |
| ジャーナル | PLoS Genet |
| Abstract |
Males of the Drosophila melanogaster mutant croaker (cro) generate a polycyclic pulse song dissimilar to the monocyclic songs typical of wild-type males during courtship. However, cro has not been molecularly mapped to any gene in the genome. We demonstrate that cro is a mutation in the gene encoding the Calmodulin-binding transcription factor (Camta) by genetic complementation tests with chromosomal deficiencies, molecular cloning of genomic fragments that flank the cro-mutagenic P-insertion, and phenotypic rescue of the cro mutant phenotype by Camta+-encoding cDNA as well as a BAC clone containing the gene for Camta. We further show that knockdown of the Camta-encoding gene phenocopies cro mutant songs when targeted to a subset of fruitless-positive neurons that include the mcALa and AL1 clusters in the brain. cro-GAL4 and an anti-Camta antibody labeled a large number of brain neurons including mcALa. We conclude that the Camta-encoding gene represents the cro locus, which has been implicated in a species-specific difference in courtship songs between D. sechellia and simulans. |
| 巻・号 | 15(7) |
| ページ | e1008309 |
| 公開日 | 2019-7-1 |
| DOI | 10.1371/journal.pgen.1008309 |
| PII | PGENETICS-D-19-00863 |
| PMID | 31344027 |
| PMC | PMC6690551 |
| MeSH | Animals Brain / metabolism Calmodulin / metabolism* Courtship Drosophila Proteins / genetics* Drosophila Proteins / metabolism Drosophila melanogaster / physiology* Genetic Complementation Test Male Sexual Behavior, Animal / physiology* Species Specificity Trans-Activators / genetics* Trans-Activators / metabolism Vocalization, Animal |
| IF | 5.175 |
| 引用数 | 1 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 13 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#150124 DGRC#104266 |