Reference - Detail
| RRC ID | 59125 |
|---|---|
| Author | Slaidina M, Banisch TU, Gupta S, Lehmann R. |
| Title | A single-cell atlas of the developing Drosophila ovary identifies follicle stem cell progenitors. |
| Journal | Genes Dev |
| Abstract |
Addressing the complexity of organogenesis at a system-wide level requires a complete understanding of adult cell types, their origin, and precursor relationships. The Drosophila ovary has been a model to study how coordinated stem cell units, germline, and somatic follicle stem cells maintain and renew an organ. However, lack of cell type-specific tools have limited our ability to study the origin of individual cell types and stem cell units. Here, we used a single-cell RNA sequencing approach to uncover all known cell types of the developing ovary, reveal transcriptional signatures, and identify cell type-specific markers for lineage tracing. Our study identifies a novel cell type corresponding to the elusive follicle stem cell precursors and predicts subtypes of known cell types. Altogether, we reveal a previously unanticipated complexity of the developing ovary and provide a comprehensive resource for the systematic analysis of ovary morphogenesis. |
| Volume | 34(3-4) |
| Pages | 239-249 |
| Published | 2020-2-1 |
| DOI | 10.1101/gad.330464.119 |
| PII | gad.330464.119 |
| PMID | 31919193 |
| PMC | PMC7000915 |
| MeSH | Animals Drosophila / cytology* Drosophila / genetics Drosophila / metabolism Female Models, Animal Ovarian Follicle / cytology* Ovary / cytology Sequence Analysis, RNA Single-Cell Analysis Stem Cells / cytology* Transcription, Genetic |
| IF | 9.527 |
| Times Cited | 1 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 15 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Drosophila | DGRC#108066 |