RRC ID 59141
Author Ramaekers A, Claeys A, Kapun M, Mouchel-Vielh E, Potier D, Weinberger S, Grillenzoni N, Dardalhon-Cuménal D, Yan J, Wolf R, Flatt T, Buchner E, Hassan BA.
Title Altering the Temporal Regulation of One Transcription Factor Drives Evolutionary Trade-Offs between Head Sensory Organs.
Journal Dev Cell
Abstract Size trade-offs of visual versus olfactory organs is a pervasive feature of animal evolution. This could result from genetic or functional constraints. We demonstrate that head sensory organ size trade-offs in Drosophila are genetically encoded and arise through differential subdivision of the head primordium into visual versus non-visual fields. We discover that changes in the temporal regulation of the highly conserved eyeless/Pax6 gene expression during development is a conserved mechanism for sensory trade-offs within and between Drosophila species. We identify a natural single nucleotide polymorphism in the cis-regulatory region of eyeless in a binding site of its repressor Cut that is sufficient to alter its temporal regulation and eye size. Because eyeless/Pax6 is a conserved regulator of head sensory placode subdivision, we propose that its temporal regulation is key to define the relative size of head sensory organs.
Volume 50(6)
Pages 780-792.e7
Published 2019-9-23
DOI 10.1016/j.devcel.2019.07.027
PII S1534-5807(19)30658-6
PMID 31447264
MeSH Animals Binding Sites Biological Evolution* DNA-Binding Proteins / genetics DNA-Binding Proteins / metabolism* Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster / genetics* Enhancer Elements, Genetic / genetics Eye / anatomy & histology Eye / metabolism Female Gene Expression Regulation, Developmental* Geography Head Nucleotides / genetics Organ Size / genetics Polymorphism, Single Nucleotide / genetics Sense Organs / metabolism* Time Factors
IF 9.19
Times Cited 8
Resource
Drosophila DGRC#105668 DGRC#104957 DGRC#103421