論文 - 詳細
| RRC ID | 59147 |
|---|---|
| 著者 | Chen DY, Crest J, Streichan SJ, Bilder D. |
| タイトル | Extracellular matrix stiffness cues junctional remodeling for 3D tissue elongation. |
| ジャーナル | Nat Commun |
| Abstract |
Organs are sculpted by extracellular as well as cell-intrinsic forces, but how collective cell dynamics are orchestrated in response to environmental cues is poorly understood. Here we apply advanced image analysis to reveal extracellular matrix-responsive cell behaviors that drive elongation of the Drosophila follicle, a model system in which basement membrane stiffness instructs three-dimensional tissue morphogenesis. Through in toto morphometric analyses of wild type and round egg mutants, we find that neither changes in average cell shape nor oriented cell division are required for appropriate organ shape. Instead, a major element is the reorientation of elongated cells at the follicle anterior. Polarized reorientation is regulated by mechanical cues from the basement membrane, which are transduced by the Src tyrosine kinase to alter junctional E-cadherin trafficking. This mechanosensitive cellular behavior represents a conserved mechanism that can elongate edgeless tubular epithelia in a process distinct from those that elongate bounded, planar epithelia. |
| 巻・号 | 10(1) |
| ページ | 3339 |
| 公開日 | 2019-7-26 |
| DOI | 10.1038/s41467-019-10874-x |
| PII | 10.1038/s41467-019-10874-x |
| PMID | 31350387 |
| PMC | PMC6659696 |
| MeSH | Animals Basement Membrane / chemistry Basement Membrane / growth & development Basement Membrane / metabolism Cadherins / genetics Cadherins / metabolism Cell Polarity Cell Shape Drosophila / chemistry Drosophila / genetics Drosophila / growth & development* Drosophila / metabolism Drosophila Proteins / genetics Drosophila Proteins / metabolism Extracellular Matrix / chemistry* Extracellular Matrix / genetics Extracellular Matrix / metabolism Female Ovarian Follicle / growth & development* Ovarian Follicle / metabolism |
| IF | 12.121 |
| 引用数 | 5 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 98 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 3.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#104055 |