RRC ID 59178
Author Molnar C, Heinen JP, Reina J, Llamazares S, Palumbo E, Breschi A, Gay M, Villarreal L, Vilaseca M, Pollarolo G, Gonzalez C.
Title The histone code reader PHD finger protein 7 controls sex-linked disparities in gene expression and malignancy in Drosophila.
Journal Sci Adv
Abstract The notable male predominance across many human cancer types remains unexplained. Here, we show that Drosophila l(3)mbt brain tumors are more invasive and develop as malignant neoplasms more often in males than in females. By quantitative proteomics, we have identified a signature of proteins that are differentially expressed between male and female tumor samples. Prominent among them is the conserved chromatin reader PHD finger protein 7 (Phf7). We show that Phf7 depletion reduces sex-dependent differences in gene expression and suppresses the enhanced malignant traits of male tumors. Our results identify potential regulators of sex-linked tumor dimorphism and show that these genes may serve as targets to suppress sex-linked malignant traits.
Volume 5(8)
Pages eaaw7965
Published 2019-8-1
DOI 10.1126/sciadv.aaw7965
PII aaw7965
PMID 31453329
PMC PMC6693905
MeSH Animals Brain Neoplasms / pathology* Drosophila Proteins / genetics* Drosophila melanogaster / genetics* Female Gene Expression / genetics Gene Expression Profiling Gene Expression Regulation / genetics* Histone Code / genetics* Homeodomain Proteins / genetics* Male Protein Kinases / genetics Sex Factors
IF 13.117
Times Cited 1
Drosophila DGRC#150208