論文 - 詳細
| RRC ID | 59181 |
|---|---|
| 著者 | Blanco-Obregon D, Katz MJ, Durrieu L, Gándara L, Wappner P. |
| タイトル | Context-specific functions of Notch in Drosophila blood cell progenitors. |
| ジャーナル | Dev Biol |
| Abstract |
Drosophila Larval hematopoiesis takes place at the lymph gland, where myeloid-like progenitors differentiate into Plasmatocytes and Crystal Cells, under regulation of conserved signaling pathways. It has been established that the Notch pathway plays a specific role in Crystal Cell differentiation and maintenance. In mammalian hematopoiesis, the Notch pathway has been proposed to fulfill broader functions, including Hematopoietic Stem Cell maintenance and cell fate decision in progenitors. In this work we describe different roles that Notch plays in the lymph gland. We show that Notch, activated by its ligand Serrate, expressed at the Posterior Signaling Center, is required to restrain Core Progenitor differentiation. We define a novel population of blood cell progenitors that we name Distal Progenitors, where Notch, activated by Serrate expressed in Lineage Specifying Cells at the Medullary Zone/Cortical Zone boundary, regulates a binary decision between Plasmatocyte and Crystal Cell fates. Thus, Notch plays context-specific functions in different blood cell progenitor populations of the Drosophila lymph gland. |
| 巻・号 | 462(1) |
| ページ | 101-115 |
| 公開日 | 2020-6-1 |
| DOI | 10.1016/j.ydbio.2020.03.018 |
| PII | S0012-1606(20)30106-8 |
| PMID | 32243888 |
| MeSH | Animals Blood Cells / cytology Cell Differentiation / physiology Cell Lineage Drosophila Proteins / metabolism Drosophila Proteins / physiology Drosophila melanogaster / metabolism Hematopoiesis / physiology Hematopoietic Stem Cells / cytology* Jagged-1 Protein / metabolism Larva / metabolism Lymph Nodes / metabolism* Receptors, Notch / metabolism* Receptors, Notch / physiology Signal Transduction / physiology |
| IF | 2.896 |
| 引用数 | 0 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 7 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#105442 |