Reference - Detail
| RRC ID | 59308 |
|---|---|
| Author | Mansouri FA, Buckley MJ, Fehring DJ, Tanaka K. |
| Title | The Role of Primate Prefrontal Cortex in Bias and Shift Between Visual Dimensions. |
| Journal | Cereb Cortex |
| Abstract |
Imaging and neural activity recording studies have shown activation in the primate prefrontal cortex when shifting attention between visual dimensions is necessary to achieve goals. A fundamental unanswered question is whether representations of these dimensions emerge from top-down attentional processes mediated by prefrontal regions or from bottom-up processes within visual cortical regions. We hypothesized a causative link between prefrontal cortical regions and dimension-based behavior. In large cohorts of humans and macaque monkeys, performing the same attention shifting task, we found that both species successfully shifted between visual dimensions, but both species also showed a significant behavioral advantage/bias to a particular dimension; however, these biases were in opposite directions in humans (bias to color) versus monkeys (bias to shape). Monkeys' bias remained after selective bilateral lesions within the anterior cingulate cortex (ACC), frontopolar cortex, dorsolateral prefrontal cortex (DLPFC), orbitofrontal cortex (OFC), or superior, lateral prefrontal cortex. However, lesions within certain regions (ACC, DLPFC, or OFC) impaired monkeys' ability to shift between these dimensions. We conclude that goal-directed processing of a particular dimension for the executive control of behavior depends on the integrity of prefrontal cortex; however, representation of competing dimensions and bias toward them does not depend on top-down prefrontal-mediated processes. |
| Volume | 30(1) |
| Pages | 85-99 |
| Published | 2020-1-10 |
| DOI | 10.1093/cercor/bhz072 |
| PII | 5437662 |
| PMID | 31220222 |
| PMC | PMC7029686 |
| MeSH | Adolescent Adult Animals Attention / physiology* Executive Function / physiology* Female Goals Humans Macaca fuscata Macaca mulatta Male Neural Pathways / physiology Photic Stimulation Prefrontal Cortex / physiology* Psychomotor Performance Species Specificity Visual Perception / physiology* Young Adult |
| IF | 5.437 |
| Times Cited | 1 |
| Altmetric score |
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Japanese macaques | |