論文 - 詳細
| RRC ID | 59328 |
|---|---|
| 著者 | Chisnell P, Parenteau TR, Tank E, Ashrafi K, Kenyon C. |
| タイトル | The mTOR Target S6 Kinase Arrests Development in Caenorhabditis elegans When the Heat-Shock Transcription Factor Is Impaired. |
| ジャーナル | Genetics |
| Abstract |
The widely conserved heat-shock response, regulated by heat-shock transcription factors, is not only essential for cellular stress resistance and adult longevity, but also for proper development. However, the genetic mechanisms by which heat-shock transcription factors regulate development are not well understood. In Caenorhabditis elegans, we conducted an unbiased genetic screen to identify mutations that could ameliorate the developmental-arrest phenotype of a heat-shock factor mutant. Here, we show that loss of the conserved translational activator rsks-1/S6 kinase, a downstream effector of mechanistic Target of Rapamycin (mTOR) kinase, can rescue the developmental-arrest phenotype of hsf-1 partial loss-of-function mutants. Unexpectedly, we show that the rescue is not likely caused by reduced translation, nor by activation of any of a variety of stress-protective genes and pathways. Our findings identify an as-yet unexplained regulatory relationship between the heat-shock transcription factor and the mTOR pathway during C. elegans development. |
| 巻・号 | 210(3) |
| ページ | 999-1009 |
| 公開日 | 2018-11-1 |
| DOI | 10.1534/genetics.118.301533 |
| PII | genetics.118.301533 |
| PMID | 30228197 |
| PMC | PMC6218238 |
| MeSH | Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / growth & development* Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics* Caenorhabditis elegans Proteins / metabolism* Gene Deletion* Ribosomal Protein S6 Kinases, 70-kDa / deficiency Ribosomal Protein S6 Kinases, 70-kDa / genetics Ribosomal Protein S6 Kinases, 70-kDa / metabolism* TOR Serine-Threonine Kinases / metabolism* Transcription Factors / genetics* Transcription Factors / metabolism* |
| IF | 3.564 |
| 引用数 | 1 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm5213 tm5397 |