Reference - Detail
| RRC ID | 59346 |
|---|---|
| Author | Gao K, Li Y, Hu S, Liu Y. |
| Title | SUMO peptidase ULP-4 regulates mitochondrial UPR-mediated innate immunity and lifespan extension. |
| Journal | Elife |
| Abstract |
Animals respond to mitochondrial stress with the induction of mitochondrial unfolded protein response (UPRmt). A cascade of events occur upon UPRmt activation, ultimately triggering a transcriptional response governed by two transcription factors: DVE-1 and ATFS-1. Here we identify SUMO-specific peptidase ULP-4 as a positive regulator of C. elegans UPRmt to control SUMOylation status of DVE-1 and ATFS-1. SUMOylation affects these two axes in the transcriptional program of UPRmt with distinct mechanisms: change of DVE-1 subcellular localization vs. change of ATFS-1 stability and activity. Our findings reveal a post-translational modification that promotes immune response and lifespan extension during mitochondrial stress. |
| Volume | 8 |
| Published | 2019-1-15 |
| DOI | 10.7554/eLife.41792 |
| PII | 41792 |
| PMID | 30642431 |
| PMC | PMC6355198 |
| MeSH | Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / immunology* Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Cysteine Endopeptidases / genetics Cysteine Endopeptidases / metabolism* Immunity, Innate* Longevity / physiology* Lysine / metabolism Mitochondria / metabolism* Models, Biological Protein Stability Signal Transduction Sumoylation Transcription, Genetic Unfolded Protein Response* |
| IF | 7.551 |
| Times Cited | 4 |
| Resource | |
| C.elegans | tm1597 tm4525 |