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Species Resource Title
Human and Animal Cells PC-9(RCB4455) TRIM28 is a distinct prognostic biomarker that worsens the tumor immune microenvironment in lung adenocarcinoma.
C.elegans tm6658 , tm544 , tm6724 USP7 and VCPFAF1 define the SUMO/Ubiquitin landscape at the DNA replication fork.
Yeast FY23931 , FY16386 , FY25693 Smc5/6 Complex Promotes Rad3ATR Checkpoint Signaling at the Perturbed Replication Fork through Sumoylation of the RecQ Helicase Rqh1.
DNA material pCAG-HIVgp (RDB04394) , pCMV-VSV-G-RSV-Rev (RDB04393) Long-term expression of the lamin A mutant associated with dilated cardiomyopathy induces senescence.
Human and Animal Cells 293T(RCB2202) Structural alteration of DNA induced by viral protein R of HIV-1 triggers the DNA damage response.
C.elegans tm1597 , tm4525 SUMO peptidase ULP-4 regulates mitochondrial UPR-mediated innate immunity and lifespan extension.
C.elegans tm2610 Mitotic and Meiotic Functions for the SUMOylation Pathway in the Caenorhabditis elegans Germline.
Human and Animal Cells ATDC5(RCB0565) A post-translational modification cascade employing HDAC9-PIASy-RNF4 axis regulates chondrocyte hypertrophy by modulating Nkx3.2 protein stability.
Yeast K. maxianus BY28356 SUMO targeting of a stress-tolerant Ulp1 SUMO protease.
DNA material pFLAG-FIP1L1-PDGFRA-FL (RDB15460) , pFLAG-FIP1L1-PDGFRA-KD (RDB15461) , pFLAG-PDGFRA-C (RDB15462) , pCGT-FIP1L1-PDGFRA-FL (RDB15463) , pCGT-FIP1L1-PDGFRA-KD (RDB15464) , pCGT-PDGFRAC (RDB15465). Leukemogenic kinase FIP1L1-PDGFRA and a small ubiquitin-like modifier E3 ligase, PIAS1, form a positive cross-talk through their enzymatic activities.
C.elegans tm1620 , tm1400 The shelterin protein POT-1 anchors Caenorhabditis elegans telomeres through SUN-1 at the nuclear periphery.
C.elegans tm1611 , tm1991 Conversion of the LIN-1 ETS protein of Caenorhabditis elegans from a SUMOylated transcriptional repressor to a phosphorylated transcriptional activator.
C.elegans tm2176 New Insights into the Post-Translational Regulation of DNA Damage Response and Double-Strand Break Repair in Caenorhabditis elegans.
Drosophila 2411R-1 SUMO regulates somatic cyst stem cell maintenance and directly targets the Hedgehog pathway in adult Drosophila testis.
DNA material pRSFlag_mmSumo1 (RDB06126) Necdin promotes ubiquitin-dependent degradation of PIAS1 SUMO E3 ligase.
Human and Animal Cells 293(RCB1637) Characterization of a novel posttranslational modification in neuronal nitric oxide synthase by small ubiquitin-related modifier-1.
Human and Animal Cells HeLa(RCB0007) β-catenin inhibits promyelocytic leukemia protein tumor suppressor function in colorectal cancer cells.
Drosophila smt3 , 17090R-1 , 17090R-2 Drosophila Smt3 negatively regulates JNK signaling through sequestering Hipk in the nucleus.