論文 - 詳細
| RRC ID | 59354 |
|---|---|
| 著者 | Harris G, Wu T, Linfield G, Choi MK, Liu H, Zhang Y. |
| タイトル | Molecular and cellular modulators for multisensory integration in C. elegans. |
| ジャーナル | PLoS Genet |
| Abstract |
In the natural environment, animals often encounter multiple sensory cues that are simultaneously present. The nervous system integrates the relevant sensory information to generate behavioral responses that have adaptive values. However, the neuronal basis and the modulators that regulate integrated behavioral response to multiple sensory cues are not well defined. Here, we address this question using a behavioral decision in C. elegans when the animal is presented with an attractive food source together with a repulsive odorant. We identify specific sensory neurons, interneurons and neuromodulators that orchestrate the decision-making process, suggesting that various states and contexts may modulate the multisensory integration. Among these modulators, we characterize a new function of a conserved TGF-β pathway that regulates the integrated decision by inhibiting the signaling from a set of central neurons. Interestingly, we find that a common set of modulators, including the TGF-β pathway, regulate the integrated response to the pairing of different foods and repellents. Together, our results provide mechanistic insights into the modulatory signals regulating multisensory integration. |
| 巻・号 | 15(3) |
| ページ | e1007706 |
| 公開日 | 2019-3-1 |
| DOI | 10.1371/journal.pgen.1007706 |
| PII | PGENETICS-D-18-01834 |
| PMID | 30849079 |
| PMC | PMC6426271 |
| MeSH | Animals Animals, Genetically Modified Behavior, Animal / physiology Caenorhabditis elegans / genetics Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / physiology Food Genes, Helminth Interneurons / physiology Ketones Mutation Neuropeptides / genetics Neuropeptides / physiology Neurotransmitter Agents / physiology Odorants Receptors, Cell Surface / genetics Receptors, Cell Surface / physiology Sensory Receptor Cells / physiology Signal Transduction Transforming Growth Factor beta / genetics Transforming Growth Factor beta / physiology |
| IF | 5.224 |
| 引用数 | 0 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm3579 tm2416 tm2001 tm2105 tm2984 |