論文 - 詳細
| RRC ID | 59375 |
|---|---|
| 著者 | Liu X, Guo X, Niu L, Li X, Sun F, Hu J, Wang X, Shen K. |
| タイトル | Atlastin-1 regulates morphology and function of endoplasmic reticulum in dendrites. |
| ジャーナル | Nat Commun |
| Abstract |
Endoplasmic reticulum (ER) is characterized by interconnected tubules and sheets. Neuronal ER adopts specific morphology in axons, dendrites and soma. Here we study mechanisms underlying ER morphogenesis in a C. elegans sensory neuron PVD. In PVD soma and dendrite branch points, ER tubules connect to form networks. ER tubules fill primary dendrites but only extend to some but not all dendritic branches. We find that the Atlastin-1 ortholog, atln-1 is required for neuronal ER morphology. In atln-1 mutants with impaired GTPase activity, ER networks in soma and dendrite branch points are reduced and replaced by tubules, and ER tubules retracted from high-order dendritic branches, causing destabilized microtubule in these branches. The abnormal ER morphology likely causes defects in mitochondria fission at dendritic branch points. Mutant alleles of Atlastin-1 found in Hereditary Spastic Paraplegia (HSP) patients show similar ER phenotypes, suggesting that neuronal ER impairment contributes to HSP disease pathogenesis. |
| 巻・号 | 10(1) |
| ページ | 568 |
| 公開日 | 2019-2-4 |
| DOI | 10.1038/s41467-019-08478-6 |
| PII | 10.1038/s41467-019-08478-6 |
| PMID | 30718476 |
| PMC | PMC6362286 |
| MeSH | Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Dendrites / genetics Dendrites / metabolism* Endoplasmic Reticulum / genetics Endoplasmic Reticulum / metabolism* GTP-Binding Proteins / genetics GTP-Binding Proteins / metabolism Membrane Proteins / genetics Membrane Proteins / metabolism Microtubules / metabolism Spastic Paraplegia, Hereditary / genetics Spastic Paraplegia, Hereditary / metabolism |
| IF | 11.878 |
| 引用数 | 5 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm3667 tm683 tm390 |