Reference - Detail
| RRC ID | 59394 |
|---|---|
| Author | Okahata M, Wei AD, Ohta A, Kuhara A. |
| Title | Cold acclimation via the KQT-2 potassium channel is modulated by oxygen in Caenorhabditis elegans. |
| Journal | Sci Adv |
| Abstract |
Adaptive responses to external temperatures are essential for survival in changing environments. We show here that environmental oxygen concentration affects cold acclimation in Caenorhabditis elegans and that this response is regulated by a KCNQ-type potassium channel, KQT-2. Depending on culture conditions, kqt-2 mutants showed supranormal cold acclimation, caused by abnormal thermosensation in ADL chemosensory neurons. ADL neurons are responsive to temperature via transient receptor potential channels-OSM-9, OCR-2, and OCR-1-with OCR-1 negatively regulating ADL function. Similarly, KQT-2 and KQT-3 regulate ADL activity, with KQT-2 positively regulating ADL function. Abnormal cold acclimation and acute temperature responses of ADL neurons in kqt-2 mutants were suppressed by an oxygen-receptor mutation in URX coelomic sensory neurons, which are electrically connected to ADL via RMG interneurons. Likewise, low oxygen suppressed supranormal kqt-2 cold acclimation. These data thus demonstrate a simple neuronal circuit integrating two different sensory modalities, temperature and oxygen, that determines cold acclimation. |
| Volume | 5(2) |
| Pages | eaav3631 |
| Published | 2019-2-1 |
| DOI | 10.1126/sciadv.aav3631 |
| PII | aav3631 |
| PMID | 30775442 |
| PMC | PMC6365114 |
| MeSH | Acclimatization* Animals Caenorhabditis elegans / physiology* Cold Temperature* Gene Expression KCNQ2 Potassium Channel / genetics KCNQ2 Potassium Channel / metabolism* Models, Biological Mutation Oxygen / metabolism* Sensory Receptor Cells / metabolism |
| IF | 12.804 |
| Times Cited | 1 |
| Altmetric score |
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 7 |
| Altmetric score changes over past 6months | 3.0 |
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