論文 - 詳細
| RRC ID | 59447 |
|---|---|
| 著者 | Baraldo G, Etemad S, Weiss AKH, Jansen-Dürr P, Mack HID. |
| タイトル | Modulation of serotonin signaling by the putative oxaloacetate decarboxylase FAHD-1 in Caenorhabditis elegans. |
| ジャーナル | PLoS One |
| Abstract |
Human fumarylacetoacetate hydrolase (FAH) domain containing protein 1 (FAHD1) is a mitochondrial oxalocatate decarboxylase, the first of its kind identified in eukaryotes. The physiological role of FAHD1 in other eukaryotes is still poorly understood. In C. elegans loss of the FAHD1 ortholog FAHD-1 was reported to impair mitochondrial function, locomotion and egg-laying behavior, yet the underlying mechanisms remained unclear. Using tissue-specific rescue of fahd-1(-) worms, we find that these phenotypic abnormalities are at least in part due to fahd-1's function in neurons. Moreover, we show that egg-laying defects in fahd-1(-) worms can be fully rescued by external dopamine administration and that depletion of fahd-1 expression induces expression of several enzymes involved in serotonin biosynthesis. Together, our results support a role for fahd-1 in modulating serotonin levels and suggest this protein as a novel link between metabolism and neurotransmitter signaling in the nervous system. Finally, we propose a model to explain how a metabolic defect could ultimately lead to marked changes in neuronal signaling. |
| 巻・号 | 14(8) |
| ページ | e0220434 |
| 公開日 | 2019-1-1 |
| DOI | 10.1371/journal.pone.0220434 |
| PII | PONE-D-18-26906 |
| PMID | 31412049 |
| PMC | PMC6693844 |
| MeSH | Animals Animals, Genetically Modified Behavior, Animal / drug effects Behavior, Animal / physiology Caenorhabditis elegans Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Carboxy-Lyases / genetics Carboxy-Lyases / metabolism* Dopamine / pharmacology Locomotion / drug effects Locomotion / physiology Mitochondria / genetics Mitochondria / metabolism Neurons / drug effects Neurons / metabolism Serotonin / metabolism* Serotonin / pharmacology Signal Transduction / drug effects Signal Transduction / physiology* |
| IF | 2.776 |
| 引用数 | 1 |
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オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm5005 |