論文 - 詳細
| RRC ID | 59452 |
|---|---|
| 著者 | Bhardwaj A, Pandey P, Babu K. |
| タイトル | Control of Locomotory Behavior of Caenorhabditis elegans by the Immunoglobulin Superfamily Protein RIG-3. |
| ジャーナル | Genetics |
| Abstract |
Cell surface immunoglobulin superfamily (IgSF) proteins play important roles in the development and function of the nervous system . Here we define the role of a Caenorhabditis elegans IgSF protein, RIG-3, in the function of the AVA command interneuron. This study reveals that RIG-3 regulates the abundance of the glutamate receptor subunit, GLR-1, in the AVA command interneuron and also regulates reversal behavior in C. elegans The mutant strain lacking rig-3 (rig-3 (ok2156)) shows increased reversal frequency during local search behaviors. Genetic and behavioral experiments suggest that RIG-3 functions through GLR-1 to regulate reversal behavior. We also show that the increased reversal frequency seen in rig-3 mutants is dependent on the increase in GLR-1 abundance at synaptic inputs to AVA, suggesting that RIG-3 alters the synaptic strength of incoming synapses through GLR-1 Consistent with the imaging experiments, altered synaptic strength was also reflected in increased calcium transients in rig-3 mutants when compared to wild-type control animals. Our results further suggest that animals lacking rig-3 show increased AVA activity, allowing the release of FLP-18 neuropeptide from AVA, which is an activity-dependent signaling molecule. Finally, we show that FLP-18 functions through the neuropeptide receptor, NPR-5, to modulate reversal behavior in C. elegans. |
| 巻・号 | 214(1) |
| ページ | 135-145 |
| 公開日 | 2020-1-1 |
| DOI | 10.1534/genetics.119.302872 |
| PII | genetics.119.302872 |
| PMID | 31740450 |
| PMC | PMC6944407 |
| MeSH | Animals Animals, Genetically Modified / physiology Behavior, Animal / physiology Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Calcium / metabolism Cell Adhesion Molecules / genetics Cell Adhesion Molecules / metabolism* Interneurons / physiology* Locomotion / physiology* Mutation Neuropeptides / genetics Neuropeptides / metabolism Receptors, AMPA / genetics Receptors, AMPA / metabolism Signal Transduction Synapses / physiology |
| IF | 3.564 |
| 引用数 | 0 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 21 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1782 |