| RRC ID |
59473
|
| 著者 |
Cohen-Berkman M, Dudkevich R, Ben-Hamo S, Fishman A, Salzberg Y, Waldman Ben-Asher H, Lamm AT, Henis-Korenblit S.
|
| タイトル |
Endogenous siRNAs promote proteostasis and longevity in germline-less Caenorhabditis elegans.
|
| ジャーナル |
Elife
|
| Abstract |
How lifespan and the rate of aging are set is a key problem in biology. Small RNAs are conserved molecules that impact diverse biological processes through the control of gene expression. However, in contrast to miRNAs, the role of endo-siRNAs in aging remains unexplored. Here, by combining deep sequencing and genomic and genetic approaches in Caenorhabditis elegans, we reveal an unprecedented role for endo-siRNA molecules in the maintenance of proteostasis and lifespan extension in germline-less animals. Furthermore, we identify an endo-siRNA-regulated tyrosine phosphatase, which limits the longevity of germline-less animals by restricting the activity of the heat shock transcription factor HSF-1. Altogether, our findings point to endo-siRNAs as a link between germline removal and the HSF-1 proteostasis and longevity-promoting somatic pathway. This establishes a role for endo siRNAs in the aging process and identifies downstream genes and physiological processes that are regulated by the endo siRNAs to affect longevity.
|
| 巻・号 |
9
|
| 公開日 |
2020-3-26
|
| DOI |
10.7554/eLife.50896
|
| PII |
50896
|
| PMID |
32213289
|
| PMC |
PMC7136021
|
| MeSH |
Animals
Caenorhabditis elegans / physiology*
Caenorhabditis elegans Proteins / physiology
Germ Cells / physiology*
Heat-Shock Response
Longevity / physiology*
Protein Tyrosine Phosphatases / genetics
Protein Tyrosine Phosphatases / physiology
Proteostasis / physiology*
RNA, Small Interfering / physiology*
Transcription Factors / physiology
|
| IF |
7.551
|
| 引用数 |
0
|
| リソース情報 |
| 線虫 |
tm6122 |
