論文 - 詳細
| RRC ID | 59473 |
|---|---|
| 著者 | Cohen-Berkman M, Dudkevich R, Ben-Hamo S, Fishman A, Salzberg Y, Waldman Ben-Asher H, Lamm AT, Henis-Korenblit S. |
| タイトル | Endogenous siRNAs promote proteostasis and longevity in germline-less Caenorhabditis elegans. |
| ジャーナル | Elife |
| Abstract |
How lifespan and the rate of aging are set is a key problem in biology. Small RNAs are conserved molecules that impact diverse biological processes through the control of gene expression. However, in contrast to miRNAs, the role of endo-siRNAs in aging remains unexplored. Here, by combining deep sequencing and genomic and genetic approaches in Caenorhabditis elegans, we reveal an unprecedented role for endo-siRNA molecules in the maintenance of proteostasis and lifespan extension in germline-less animals. Furthermore, we identify an endo-siRNA-regulated tyrosine phosphatase, which limits the longevity of germline-less animals by restricting the activity of the heat shock transcription factor HSF-1. Altogether, our findings point to endo-siRNAs as a link between germline removal and the HSF-1 proteostasis and longevity-promoting somatic pathway. This establishes a role for endo siRNAs in the aging process and identifies downstream genes and physiological processes that are regulated by the endo siRNAs to affect longevity. |
| 巻・号 | 9 |
| 公開日 | 2020-3-26 |
| DOI | 10.7554/eLife.50896 |
| PII | 50896 |
| PMID | 32213289 |
| PMC | PMC7136021 |
| MeSH | Animals Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / physiology Germ Cells / physiology* Heat-Shock Response Longevity / physiology* Protein Tyrosine Phosphatases / genetics Protein Tyrosine Phosphatases / physiology Proteostasis / physiology* RNA, Small Interfering / physiology* Transcription Factors / physiology |
| IF | 7.551 |
| 引用数 | 0 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm6122 |