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  • Search Condition : Filter (MeSH = Protein Tyrosine Phosphatases / genetics)
Species Resource Title
Human and Animal Cells SHP1^(-) DT40(RCB1466) , SHP1^(-)/SHP2^(-) DT40(RCB1501) , SHP2^(-) DT40(RCB1502) , SHIP^(-) DT40(RCB1465) Src homology 2 domain-containing protein-tyrosine phosphatases, SHP-1 and SHP-2, are required for platelet endothelial cell adhesion molecule-1/CD31-mediated inhibitory signaling.
Drosophila DGRC#142132 , DGRC#112951 Phosphatase of Regenerating Liver-1 Selectively Times Circadian Behavior in Darkness via Function in PDF Neurons and Dephosphorylation of TIMELESS.
Drosophila DGRC#202239 Condition-dependent functional shift of two Drosophila Mtmr lipid phosphatases in autophagy control.
Human and Animal Cells GCIY(RCB0555) , Kato III(RCB2088) , MKN74(RCB1002) , NUGC-4(RCB1939) Therapeutic potential of PRL-3 targeting and clinical significance of PRL-3 genomic amplification in gastric cancer.
Human and Animal Cells RAW 264(RCB0535) , COS-7(RCB0539) A novel mitogen-activated protein kinase phosphatase is an important negative regulator of lipopolysaccharide-mediated c-Jun N-terminal kinase activation in mouse macrophage cell lines.
Silkworms A mitochondrial phosphatase PTPMT1 is essential for the early development of silkworm, Bombyx mori.
Yeast Clp1p and Mid1p form links between cell cycle progression and gene expression at cytokinesis in fission yeast.
Human and Animal Cells Sawano(RCB1152) Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway.
C.elegans tm6122 Endogenous siRNAs promote proteostasis and longevity in germline-less Caenorhabditis elegans.
C.elegans tm1734 Lineage context switches the function of a C. elegans Pax6 homolog in determining a neuronal fate.
Drosophila DGRC#102398 WASH phosphorylation balances endosomal versus cortical actin network integrities during epithelial morphogenesis.
C.elegans tm1523 Wnt signalling requires MTM-6 and MTM-9 myotubularin lipid-phosphatase function in Wnt-producing cells.
C.elegans tm591 Six and Eya promote apoptosis through direct transcriptional activation of the proapoptotic BH3-only gene egl-1 in Caenorhabditis elegans.
C.elegans tm853 Regulation of Caenorhabditis elegans p53/CEP-1-dependent germ cell apoptosis by Ras/MAPK signaling.
Human and Animal Cells HuH-7(RCB1366) Glucose enhances protein tyrosine phosphatase 1B gene transcription in hepatocytes.
Human and Animal Cells BHK-21(RCB1423) Essential domain of receptor tyrosine phosphatase beta (RPTPbeta) for interaction with Helicobacter pylori vacuolating cytotoxin.
Human and Animal Cells Hep G2(RCB0459) Negative regulation of Fas-mediated apoptosis by FAP-1 in human cancer cells.
Drosophila The role of Bro1- domain-containing protein Myopic in endosomal trafficking of Wnt/Wingless.
Yeast NA The protein phosphatase Siw14 controls caffeine-induced nuclear localization and phosphorylation of Gln3 via the type 2A protein phosphatases Pph21 and Pph22 in Saccharomyces cerevisiae.
Yeast NA Functionally redundant protein phosphatase genes PTP2 and MSG5 co-regulate the calcium signaling pathway in Saccharomyces cerevisiae upon exposure to high extracellular calcium concentration.