論文 - 詳細
| RRC ID | 59479 |
|---|---|
| 著者 | Deng T, Stempor P, Appert A, Daube M, Ahringer J, Hajnal A, Lattmann E. |
| タイトル | The Caenorhabditis elegans homolog of the Evi1 proto-oncogene, egl-43, coordinates G1 cell cycle arrest with pro-invasive gene expression during anchor cell invasion. |
| ジャーナル | PLoS Genet |
| Abstract |
Cell invasion allows cells to migrate across compartment boundaries formed by basement membranes. Aberrant cell invasion is a first step during the formation of metastases by malignant cancer cells. Anchor cell (AC) invasion in C. elegans is an excellent in vivo model to study the regulation of cell invasion during development. Here, we have examined the function of egl-43, the homolog of the human Evi1 proto-oncogene (also called MECOM), in the invading AC. egl-43 plays a dual role in this process, firstly by imposing a G1 cell cycle arrest to prevent AC proliferation, and secondly, by activating pro-invasive gene expression. We have identified the AP-1 transcription factor fos-1 and the Notch homolog lin-12 as critical egl-43 targets. A positive feedback loop between fos-1 and egl-43 induces pro-invasive gene expression in the AC, while repression of lin-12 Notch expression by egl-43 ensures the G1 cell cycle arrest necessary for invasion. Reducing lin-12 levels in egl-43 depleted animals restored the G1 arrest, while hyperactivation of lin-12 signaling in the differentiated AC was sufficient to induce proliferation. Taken together, our data have identified egl-43 Evi1 as an important factor coordinating cell invasion with cell cycle arrest. |
| 巻・号 | 16(3) |
| ページ | e1008470 |
| 公開日 | 2020-3-1 |
| DOI | 10.1371/journal.pgen.1008470 |
| PII | PGENETICS-D-19-01671 |
| PMID | 32203506 |
| PMC | PMC7117773 |
| MeSH | Animals Basement Membrane / metabolism Caenorhabditis elegans / genetics* Caenorhabditis elegans Proteins / genetics* Cell Cycle Checkpoints / genetics* Cell Differentiation / genetics Cell Proliferation / genetics G1 Phase Cell Cycle Checkpoints / genetics* Gene Expression / genetics* MDS1 and EVI1 Complex Locus Protein / genetics* Proto-Oncogene Mas Proto-Oncogene Proteins c-fos / genetics Proto-Oncogenes / genetics* Receptors, Notch / genetics Signal Transduction / genetics Transcription Factors / genetics |
| IF | 5.224 |
| 引用数 | 0 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1802 |