論文 - 詳細
| RRC ID | 59518 |
|---|---|
| 著者 | Kawamura K, Maruyama IN. |
| タイトル | Forward Genetic Screen for Caenorhabditis elegans Mutants with a Shortened Locomotor Healthspan. |
| ジャーナル | G3 (Bethesda) |
| Abstract |
Two people with the same lifespan do not necessarily have the same healthspan. One person may retain locomotor and cognitive abilities until the end of life, while another person may lose them during adulthood. Unbiased searches for genes that are required to maintain locomotor ability during adulthood may uncover key regulators of locomotor healthspan. Here, we take advantage of the relatively short lifespan of the nematode Caenorhabditis elegans and develop a novel screening procedure to collect mutants with locomotor deficits that become apparent in adulthood. After ethyl methanesulfonate mutagenesis, we isolated five C. elegans mutant strains that progressively lose adult locomotor ability. In one of the mutant strains, a nonsense mutation in elpc-2, which encodes Elongator Complex Protein Component 2, causes a progressive decline in locomotor ability during adulthood. Mutants and mutations identified in the present screen may provide insights into mechanisms of age-related locomotor impairment and the maintenance of locomotor healthspan. |
| 巻・号 | 9(8) |
| ページ | 2415-2423 |
| 公開日 | 2019-8-8 |
| DOI | 10.1534/g3.119.400241 |
| PII | g3.119.400241 |
| PMID | 31213517 |
| PMC | PMC6686916 |
| MeSH | Animals Caenorhabditis elegans / genetics* Caenorhabditis elegans Proteins / genetics* Genetic Association Studies Locomotion* Mutation* Phenotype* |
| IF | 2.63 |
| 引用数 | 0 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm2149 tm1297 |