論文 - 詳細
| RRC ID | 59531 |
|---|---|
| 著者 | Lee HJ, Noormohammadi A, Koyuncu S, Calculli G, Simic MS, Herholz M, Trifunovic A, Vilchez D. |
| タイトル | Prostaglandin signals from adult germ stem cells delay somatic aging of Caenorhabditis elegans. |
| ジャーナル | Nat Metab |
| Abstract |
A moderate reduction of body temperature can induce a remarkable lifespan extension. Here we examine the link between cold temperature, germ line fitness and organismal longevity. We show that low temperature reduces age-associated exhaustion of germ stem cells (GSCs) in Caenorhabditis elegans, a process modulated by thermosensory neurons. Notably, robust self-renewal of adult GSCs delays reproductive aging and is required for extended lifespan at cold temperatures. These cells release prostaglandin E2 (PGE2) to induce cbs-1 expression in the intestine, increasing somatic production of hydrogen sulfide (H2S), a gaseous signaling molecule that prolongs lifespan. Whereas loss of adult GSCs reduces intestinal cbs-1 expression and cold-induced longevity, application of exogenous PGE2 rescues these phenotypes. Importantly, tissue-specific intestinal overexpression of cbs-1 mimics cold-temperature conditions and extends longevity even at warm temperatures. Thus, our results indicate that GSCs communicate with somatic tissues to coordinate extended reproductive capacity with longevity. |
| 巻・号 | 1(8) |
| ページ | 790-810 |
| 公開日 | 2019-8-1 |
| DOI | 10.1038/s42255-019-0097-9 |
| PII | 10.1038/s42255-019-0097-9 |
| PMID | 31485561 |
| PMC | PMC6726479 |
| MeSH | Animals Caenorhabditis elegans / physiology* Longevity / physiology* Prostaglandins / metabolism* Signal Transduction* Stem Cells / metabolism* |
| 引用数 | 4 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 84 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm483 |