| RRC ID |
59531
|
| 著者 |
Lee HJ, Noormohammadi A, Koyuncu S, Calculli G, Simic MS, Herholz M, Trifunovic A, Vilchez D.
|
| タイトル |
Prostaglandin signals from adult germ stem cells delay somatic aging of Caenorhabditis elegans.
|
| ジャーナル |
Nat Metab
|
| Abstract |
A moderate reduction of body temperature can induce a remarkable lifespan extension. Here we examine the link between cold temperature, germ line fitness and organismal longevity. We show that low temperature reduces age-associated exhaustion of germ stem cells (GSCs) in Caenorhabditis elegans, a process modulated by thermosensory neurons. Notably, robust self-renewal of adult GSCs delays reproductive aging and is required for extended lifespan at cold temperatures. These cells release prostaglandin E2 (PGE2) to induce cbs-1 expression in the intestine, increasing somatic production of hydrogen sulfide (H2S), a gaseous signaling molecule that prolongs lifespan. Whereas loss of adult GSCs reduces intestinal cbs-1 expression and cold-induced longevity, application of exogenous PGE2 rescues these phenotypes. Importantly, tissue-specific intestinal overexpression of cbs-1 mimics cold-temperature conditions and extends longevity even at warm temperatures. Thus, our results indicate that GSCs communicate with somatic tissues to coordinate extended reproductive capacity with longevity.
|
| 巻・号 |
1(8)
|
| ページ |
790-810
|
| 公開日 |
2019-8-1
|
| DOI |
10.1038/s42255-019-0097-9
|
| PII |
10.1038/s42255-019-0097-9
|
| PMID |
31485561
|
| PMC |
PMC6726479
|
| MeSH |
Animals
Caenorhabditis elegans / physiology*
Longevity / physiology*
Prostaglandins / metabolism*
Signal Transduction*
Stem Cells / metabolism*
|
| 引用数 |
4
|
| リソース情報 |
| 線虫 |
tm483 |
