RRC ID 59538
著者 Lin C, Lin Y, Chen Y, Xu J, Li J, Cao Y, Su Z, Chen Y.
タイトル Effects of Momordica saponin extract on alleviating fat accumulation in Caenorhabditis elegans.
ジャーナル Food Funct
Abstract Momordica saponins have diverse biological activities and are widely used to improve obesity. Here, we investigated the alleviation of fat accumulation and mechanism of action of the saponin-enriched ethanol extract from Momordica charantia (MSE) in Caenorhabditis elegans (C. elegans). First, MSE had a strong fat-reduction capacity in normal and high-fat worms. Second, MSE significantly increased the proportion of small lipid droplets and reduced the average particle size in ZXW618. Meanwhile, it improved lifespan and healthspan and physiological functions, such as age pigmentation and neuroprotection. Furthermore, MSE mediated fat reduction gets involved neither in energy intake nor in energy expenditure. Finally, MSE might down-regulate sbp-1 and nhr-49 via mdt-15, and up regulate age-1 via daf-2. And these targets genes together down-regulated the expression of fat-5, fat-6 and fat-7 to decrease fat accumulation. Our results provided new insights into the inhibition of fat accumulation and underlying mechanisms of Momordica saponins in C. elegans, which might be developed into a nutraceutical to ameliorate obesity.
巻・号 10(6)
ページ 3237-3251
公開日 2019-6-19
DOI 10.1039/c9fo00254e
PMID 31089601
MeSH Animals Caenorhabditis elegans / drug effects* Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Fats / metabolism* Female Humans Male Momordica charantia / chemistry* Obesity / drug therapy* Obesity / genetics Obesity / metabolism Plant Extracts / administration & dosage* Saponins / administration & dosage*
IF 3.241
引用数 1
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