Reference - Detail
| RRC ID | 59605 |
|---|---|
| Author | Suo S, Harada K, Matsuda S, Kyo K, Wang M, Maruyama K, Awaji T, Tsuboi T. |
| Title | Sexually Dimorphic Regulation of Behavioral States by Dopamine in Caenorhabditis elegans. |
| Journal | J Neurosci |
| Abstract |
Sex differences in behavior allow animals to effectively mate and reproduce. However, the mechanism by which biological sex regulates behavioral states, which underlie the regulation of sex-shared behaviors, such as locomotion, is largely unknown. In this study, we studied sex differences in the behavioral states of Caenorhabditis elegans and found that males spend less time in a low locomotor activity state than hermaphrodites and that dopamine generates this sex difference. In males, dopamine reduces the low activity state by acting in the same pathway as polycystic kidney disease-related genes that function in male-specific neurons. In hermaphrodites, dopamine increases the low activity state by suppression of octopamine signaling in the sex-shared SIA neurons, which have reduced responsiveness to octopamine in males. Furthermore, dopamine promotes exploration both inside and outside of bacterial lawn (the food source) in males and suppresses it in hermaphrodites. These results demonstrate that sexually dimorphic signaling allows the same neuromodulator to promote adaptive behavior for each sex.SIGNIFICANCE STATEMENT The mechanisms that generate sex differences in sex-shared behaviors, including locomotion, are not well understood. We show that there are sex differences in the regulation of behavioral states in the model animal Caenorhabditis elegans Dopamine promotes the high locomotor activity state in males, which must search for mates to reproduce, and suppresses it in self-fertilizing hermaphrodites through distinct molecular mechanisms. This study demonstrates that sex-specific signaling generates sex differences in the regulation of behavioral states, which in turn modulates the locomotor activity to suit reproduction for each sex. |
| Volume | 39(24) |
| Pages | 4668-4683 |
| Published | 2019-6-12 |
| DOI | 10.1523/JNEUROSCI.2985-18.2019 |
| PII | JNEUROSCI.2985-18.2019 |
| PMID | 30988167 |
| PMC | PMC6561698 |
| MeSH | Adrenergic alpha-Agonists / pharmacology Animals Animals, Genetically Modified Behavior, Animal / drug effects* Caenorhabditis elegans / physiology* Cationic Amino Acid Transporter 2 / metabolism Disorders of Sex Development Dopamine / pharmacology* Exploratory Behavior / drug effects Female Interneurons / drug effects Male Motor Activity / drug effects Receptors, Biogenic Amine / drug effects Receptors, Biogenic Amine / genetics Serotonin / pharmacology Sex Characteristics Sexual Behavior Signal Transduction / drug effects |
| IF | 6.074 |
| Times Cited | 0 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 12 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm2261 tm1996 tm2104 tm2385 tm2735 tm1392 |