論文 - 詳細
| RRC ID | 59631 |
|---|---|
| 著者 | Zaarur N, Desevin K, Mackenzie J, Lord A, Grishok A, Kandror KV. |
| タイトル | ATGL-1 mediates the effect of dietary restriction and the insulin/IGF-1 signaling pathway on longevity in C. elegans. |
| ジャーナル | Mol Metab |
| Abstract |
OBJECTIVE:Animal lifespan is controlled through genetic pathways that are conserved from nematodes to humans. Lifespan-promoting conditions in nematodes include fasting and a reduction of insulin/IGF signaling. Here we aimed to investigate the input of the Caenorhabditis elegans homologue of the mammalian rate-limiting lipolytic enzyme Adipose Triglyceride Lipase, ATGL-1, in longevity control. METHODS:We used a combination of genetic and biochemical approaches to determine the role of ATGL-1 in accumulation of triglycerides and regulation of longevity. RESULTS:We found that expression of ATGL is increased in the insulin receptor homologue mutant daf-2 in a FoxO/DAF-16-dependent manner. ATGL-1 is also up-regulated by fasting and in the eat-2 loss-of-function mutant strain. Overexpression of ATGL-1 increases basal and maximal oxygen consumption rate and extends lifespan in C. elegans. Reduction of ATGL-1 function suppresses longevity of the long-lived mutants eat-2 and daf-2. CONCLUSION:Our results demonstrate that ATGL is required for extended lifespan downstream of both dietary restriction and reduced insulin/IGF signaling. |
| 巻・号 | 27 |
| ページ | 75-82 |
| 公開日 | 2019-9-1 |
| DOI | 10.1016/j.molmet.2019.07.001 |
| PII | S2212-8778(19)30482-X |
| PMID | 31311719 |
| PMC | PMC6717769 |
| MeSH | Animals Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / metabolism* Fasting Insulin / metabolism* Insulin-Like Growth Factor I / metabolism* Lipase / metabolism* Longevity Signal Transduction* |
| IF | 6.448 |
| 引用数 | 1 |
| リソース情報 | |
| 線虫 | tm3116 |