論文 - 詳細
| RRC ID | 59634 |
|---|---|
| 著者 | Zhang Y, Qi L, Zhang H. |
| タイトル | TGFβ-like DAF-7 acts as a systemic signal for autophagy regulation in C. elegans. |
| ジャーナル | J Cell Biol |
| Abstract |
In response to stress conditions, autophagy activity in multicellular organisms is systemically modulated to ensure maintenance of cellular homeostasis at an organismal level. Very little is known about the intercellular signals that elicit the long-range organism-wide autophagy response. Here we showed that during Caenorhabditis elegans development, loss of cuticle annular furrow collagens elicits autophagy in the hypodermis, intestine, and muscle. The cilia of sensory neurons with cuticle-localized endings are essential for triggering this systemic response. The TGFβ-like molecule DAF-7, which is secreted in part from a specific pair of ciliated neurons, acts as a systemic factor that activates a canonical TGFβ signaling pathway in distant tissues to induce autophagy. We also showed that AAK-2/AMPK and the STAT-like protein STA-2 act differentially in different tissues for autophagy activation. Our study reveals a circuit that senses and transduces the signal from the damaged cuticle to activate systemic autophagy during animal development. |
| 巻・号 | 218(12) |
| ページ | 3998-4006 |
| 公開日 | 2019-12-2 |
| DOI | 10.1083/jcb.201907196 |
| PII | jcb.201907196 |
| PMID | 31658998 |
| PMC | PMC6891079 |
| MeSH | Animals Animals, Genetically Modified Autophagy* Caenorhabditis elegans / cytology* Caenorhabditis elegans Proteins / metabolism* Cilia / metabolism Gene Expression Regulation Immunity, Innate Intestines Muscles / metabolism Mutation RNA Interference STAT Transcription Factors / metabolism Sensory Receptor Cells / metabolism* Signal Transduction* Subcutaneous Tissue / metabolism Transforming Growth Factor beta / metabolism* |
| IF | 8.891 |
| 引用数 | 2 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 41 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm3425 tm4698 tm2508 |