RRC ID |
59667
|
Author |
Fujita K, Somiya M, Kuroda S, Hinuma S.
|
Title |
Induction of lipid droplets in non-macrophage cells as well as macrophages by liposomes and exosomes.
|
Journal |
Biochem Biophys Res Commun
|
Abstract |
It has been reported that phospholipid nanoparticles (PNPs) including liposomes and exosomes could efficiently induce lipid droplets (LDs) in macrophages. However, in non-macrophage cells, the effects of PNPs on the induction of LDs have not been thoroughly investigated. In this report, we directly compared non-macrophage and macrophage cell lines in terms of LD induction by various formulation of liposomes containing phosphatidylserine and exosomes. All non-macrophage cell lines as well as macrophage cell lines tested in this study showed evident LD induction in response to these PNPs, though the efficacy of LD induction in non-macrophage cell lines varied considerably. Our results suggest that LD formation is a common and crucial response to PNPs in mammalian cells not only in macrophages but also in non-macrophage cells.
|
Volume |
510(1)
|
Pages |
184-190
|
Published |
2019-2-26
|
DOI |
10.1016/j.bbrc.2019.01.078
|
PII |
S0006-291X(19)30092-0
|
PMID |
30678809
|
MeSH |
Animals
Cell Line
Exosomes / physiology*
Humans
Lipid Droplets / metabolism*
Liposomes / chemistry
Liposomes / pharmacology*
Macrophages / ultrastructure*
Nanoparticles / chemistry
Phosphatidylserines
Phospholipids
|
IF |
2.705
|
Times Cited |
1
|
Resource |
Human and Animal Cells |
NB2a(RCB2639)
293T(RCB2202)
RAW 264(RCB0535)
COS-7(RCB0539) |