論文 - 詳細
RRC ID | 59667 |
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著者 | Fujita K, Somiya M, Kuroda S, Hinuma S. |
タイトル | Induction of lipid droplets in non-macrophage cells as well as macrophages by liposomes and exosomes. |
ジャーナル | Biochem Biophys Res Commun |
Abstract |
It has been reported that phospholipid nanoparticles (PNPs) including liposomes and exosomes could efficiently induce lipid droplets (LDs) in macrophages. However, in non-macrophage cells, the effects of PNPs on the induction of LDs have not been thoroughly investigated. In this report, we directly compared non-macrophage and macrophage cell lines in terms of LD induction by various formulation of liposomes containing phosphatidylserine and exosomes. All non-macrophage cell lines as well as macrophage cell lines tested in this study showed evident LD induction in response to these PNPs, though the efficacy of LD induction in non-macrophage cell lines varied considerably. Our results suggest that LD formation is a common and crucial response to PNPs in mammalian cells not only in macrophages but also in non-macrophage cells. |
巻・号 | 510(1) |
ページ | 184-190 |
公開日 | 2019-2-26 |
DOI | 10.1016/j.bbrc.2019.01.078 |
PII | S0006-291X(19)30092-0 |
PMID | 30678809 |
MeSH | Animals Cell Line Exosomes / physiology* Humans Lipid Droplets / metabolism* Liposomes / chemistry Liposomes / pharmacology* Macrophages / ultrastructure* Nanoparticles / chemistry Phosphatidylserines Phospholipids |
IF | 2.705 |
引用数 | 1 |
リソース情報 | |
ヒト・動物細胞 | NB2a(RCB2639) 293T(RCB2202) RAW 264(RCB0535) COS-7(RCB0539) |