RRC ID 59804
Author Nakamura M, Yoshida H, Takahashi E, Wlizla M, Takebayashi-Suzuki K, Horb ME, Suzuki A.
Title The AP-1 transcription factor JunB functions in Xenopus tail regeneration by positively regulating cell proliferation.
Journal Biochem Biophys Res Commun
Abstract Xenopus tropicalis tadpoles can regenerate an amputated tail, including spinal cord, muscle and notochord, through cell proliferation and differentiation. However, the molecular mechanisms that regulate cell proliferation during tail regeneration are largely unknown. Here we show that JunB plays an important role in tail regeneration by regulating cell proliferation. The expression of junb is rapidly activated and sustained during tail regeneration. Knockout (KO) of junb causes a delay in tail regeneration and tissue differentiation. In junb KO tadpoles, cell proliferation is prevented before tissue differentiation. Furthermore, TGF-β signaling, which is activated just after tail amputation, regulates the induction and maintenance of junb expression. These findings demonstrate that JunB, a downstream component of TGF-β signaling, works as a positive regulator of cell proliferation during Xenopus tail regeneration.
Volume 522(4)
Pages 990-995
Published 2020-2-19
DOI 10.1016/j.bbrc.2019.11.060
PII S0006-291X(19)32180-1
PMID 31812242
PMC PMC6989358
MeSH Animals Cell Proliferation Down-Regulation / genetics Gene Expression Regulation, Developmental Gene Knockout Techniques Larva / physiology Regeneration / physiology* Signal Transduction Tail / physiology* Transcription Factor AP-1 / metabolism* Transforming Growth Factor beta / metabolism Xenopus / physiology*
IF 2.705
Times Cited 0
Xenopus tropicalis