RRC ID 59825
著者 Li J, Yoshida Y, Kurita M, Usuki T.
タイトル Cynaropicrin and inhibition of NF-κB activation: A structure activity relationship study.
ジャーナル Bioorg Med Chem Lett
Abstract Cynaropicrin is a guaianolide sesquiterpene lactone with a 5-7-5 tricyclic skeleton, four exo-olefins, and two hydroxyl groups. This natural product has various biological activities including anti-inflammatory properties and antitrypanosomal activity. It was also found to suppress photoaging of the skin by inhibiting the transcription activity of nuclear factor-kappa B (NF-κB). In this paper, nine chemical derivatives of cynaropicrin were prepared, and the structure activity relationship (SAR) study for NF-κB inhibition by measuring relative light units (RLU) was conducted.
巻・号 29(12)
ページ 1518-1521
公開日 2019-6-15
DOI 10.1016/j.bmcl.2019.04.004
PII S0960-894X(19)30213-6
PMID 30987894
MeSH Cytotoxins / pharmacology Cytotoxins / therapeutic use* Humans Lactones / pharmacology Lactones / therapeutic use* NF-kappa B / metabolism* Sesquiterpenes / pharmacology Sesquiterpenes / therapeutic use* Structure-Activity Relationship
IF 2.448
引用数 0
リソース情報
ヒト・動物細胞 293(RCB1637)