論文 - 詳細
| RRC ID | 59863 |
|---|---|
| 著者 | Arifuzzaman M, Ito A, Ikeda K, Kawabe Y, Kamihira M. |
| タイトル | Fabricating Muscle-Neuron Constructs with Improved Contractile Force Generation. |
| ジャーナル | Tissue Eng Part A |
| Abstract |
IMPACT STATEMENT:In this study, we fabricated innervated skeletal muscle tissue constructs comprising C2C12 myoblasts and PC12 neural cells using a magnetic force-based tissue engineering technique. We found that the C2C12/PC12 co-culture enhanced neural differentiation of PC12 cells and sarcomere formation of C2C12 myotubes, accompanying with neuromuscular junction formation. The innervated skeletal muscle tissue constructs generated significantly higher contractile forces compared with aneural (C2C12 monoculture) skeletal muscle tissue constructs. These innervated skeletal muscle tissue constructs can be a useful tool for drug testing and biological research for neuromuscular diseases. |
| 巻・号 | 25(7-8) |
| ページ | 563-574 |
| 公開日 | 2019-4-1 |
| DOI | 10.1089/ten.TEA.2018.0165 |
| PMID | 30221587 |
| MeSH | Animals Cell Differentiation / physiology Muscle Contraction / genetics Muscle Contraction / physiology* Muscle Fibers, Skeletal / cytology Muscle Fibers, Skeletal / metabolism Muscle, Skeletal / cytology* Muscle, Skeletal / innervation Muscle, Skeletal / metabolism Neuromuscular Junction / cytology Neuromuscular Junction / metabolism Neurons / cytology* Neurons / metabolism PC12 Cells Rats Sarcomeres / metabolism Tissue Engineering / methods |
| IF | 3.508 |
| 引用数 | 2 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | C2C12(RCB0987) |