RRC ID 5988
Author Domínguez-Frutos E, Vendrell V, Alvarez Y, Zelarayan LC, López-Hernández I, Ros M, Schimmang T.
Title Tissue-specific requirements for FGF8 during early inner ear development.
Journal Mech. Dev.
Abstract Several members of the FGF gene family have been shown to intervene from various tissue sources to direct otic placode induction and otic vesicle formation. In this study we define the roles of FGF8, found in different expression domains during this process, in mice and chickens. By conditional inactivation of Fgf8 in distinct tissue compartments we demonstrate that Fgf8 is required in the mesoderm and endoderm during early inner ear development. In the chicken embryo, overexpression of Fgf8 from various tissue sources during otic specification leads to a loss of otic tissue. In contrast ectopic overexpression of Fgf10, a major player during murine otic induction, does not influence otic vesicle formation in chicken embryos but results in the formation of ectopic structures with a non-otic character. This study underlines the crucial role of a defined Fgf8 expression pattern controlling inner ear formation in vertebrates.
Volume 126(10)
Pages 873-81
Published 2009-10
DOI 10.1016/j.mod.2009.07.004
PII S0925-4773(09)01308-2
PMID 19619645
MeSH Animals Chick Embryo Ear, Inner / embryology* Ear, Inner / physiology Fibroblast Growth Factor 3 / genetics Fibroblast Growth Factor 3 / physiology Fibroblast Growth Factor 8 / genetics Fibroblast Growth Factor 8 / physiology* Gene Expression Regulation, Developmental In Situ Hybridization Mice Mice, Transgenic
IF 2.176
Times Cited 14
Mice Mesp1-cre