RRC ID 59936
Author Andalman AS, Burns VM, Lovett-Barron M, Broxton M, Poole B, Yang SJ, Grosenick L, Lerner TN, Chen R, Benster T, Mourrain P, Levoy M, Rajan K, Deisseroth K.
Title Neuronal Dynamics Regulating Brain and Behavioral State Transitions.
Journal Cell
Abstract Prolonged behavioral challenges can cause animals to switch from active to passive coping strategies to manage effort-expenditure during stress; such normally adaptive behavioral state transitions can become maladaptive in psychiatric disorders such as depression. The underlying neuronal dynamics and brainwide interactions important for passive coping have remained unclear. Here, we develop a paradigm to study these behavioral state transitions at cellular-resolution across the entire vertebrate brain. Using brainwide imaging in zebrafish, we observed that the transition to passive coping is manifested by progressive activation of neurons in the ventral (lateral) habenula. Activation of these ventral-habenula neurons suppressed downstream neurons in the serotonergic raphe nucleus and caused behavioral passivity, whereas inhibition of these neurons prevented passivity. Data-driven recurrent neural network modeling pointed to altered intra-habenula interactions as a contributory mechanism. These results demonstrate ongoing encoding of experience features in the habenula, which guides recruitment of downstream networks and imposes a passive coping behavioral strategy.
Volume 177(4)
Pages 970-985.e20
Published 2019-5-2
DOI 10.1016/j.cell.2019.02.037
PII S0092-8674(19)30220-X
PMID 31031000
PMC PMC6726130
MeSH Adaptation, Psychological / physiology* Animals Behavior, Animal / physiology Brain / metabolism Habenula / metabolism Habenula / physiology* Larva Neural Pathways / metabolism Neurons / metabolism Raphe Nuclei / metabolism Serotonergic Neurons / metabolism Serotonin Stress, Physiological / physiology Zebrafish / metabolism Zebrafish Proteins / metabolism
IF 36.216
Times Cited 17
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