Reference - Detail
| RRC ID | 60010 |
|---|---|
| Author | Chia JSM, Wall ES, Wee CL, Rowland TAJ, Cheng RK, Cheow K, Guillemin K, Jesuthasan S. |
| Title | Bacteria evoke alarm behaviour in zebrafish. |
| Journal | Nat Commun |
| Abstract |
When injured, fish release an alarm substance (Schreckstoff) that elicits fear in members of their shoal. Although Schreckstoff has been proposed to be produced by club cells in the skin, several observations indicate that these giant cells function primarily in immunity. Previous data indicate that the alarm substance can be isolated from mucus. Here we show that mucus, as well as bacteria, are transported from the external surface into club cells, by cytoplasmic transfer or invasion of cells, including neutrophils. The presence of bacteria inside club cells raises the possibility that the alarm substance may contain a bacterial component. Indeed, lysate from a zebrafish Staphylococcus isolate is sufficient to elicit alarm behaviour, acting in concert with a substance from fish. These results suggest that Schreckstoff, which allows one individual to unwittingly change the emotional state of the surrounding population, derives from two kingdoms and is associated with processes that protect the host from bacteria. |
| Volume | 10(1) |
| Pages | 3831 |
| Published | 2019-8-23 |
| DOI | 10.1038/s41467-019-11608-9 |
| PII | 10.1038/s41467-019-11608-9 |
| PMID | 31444339 |
| PMC | PMC6707203 |
| MeSH | Animal Communication* Animals Animals, Genetically Modified Fear / physiology Giant Cells / metabolism Giant Cells / microbiology Intravital Microscopy Mucus / cytology Mucus / metabolism Mucus / microbiology Neutrophils / metabolism Neutrophils / microbiology Optical Imaging Reflex, Startle / physiology Skin / cytology Skin / metabolism* Skin / microbiology Staphylococcus / metabolism* Symbiosis / physiology Zebrafish / injuries Zebrafish / microbiology Zebrafish / physiology* |
| IF | 11.878 |
| Times Cited | 1 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 50 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Zebrafish | Tg(OMP:Gal4FF)rw0320 |