Reference - Detail
| RRC ID | 60019 |
|---|---|
| Author | Kobayashi Y, Shimazu T, Murata K, Itou T, Suzuki Y. |
| Title | An endogenous adeno-associated virus element in elephants. |
| Journal | Virus Res |
| Abstract |
An endogenous viral element derived from adeno-associated virus containing a nearly intact open reading frame (ORF) of the rep gene (enAAV-rep) has been identified in the genomes of various mammals including degu and African elephant. Particularly, in degu, mRNA expression of enAAV-rep has been observed specifically in the liver. Here we newly identified enAAV-rep in Asian elephant and rock hyrax, both of which are afrotherians. The enAAV-rep of African and Asian elephants appeared to be orthologous and originated from an integration event of the entire genome of AAV into the ancestral genome of elephants more than 6 million years ago, whereas that of rock hyrax appeared to have originated independently. Negative selection operating at the amino acid sequence level was detected for the ORF of enAAV-rep in elephants. As in degu, mRNA expression of enAAV-rep was specifically observed in the liver in Asian elephant. Integrations of enAAV-rep appeared to have occurred independently on the evolutionary lineages of elephants and degu, suggesting that the AAV Rep protein has been co-opted repeatedly in the mammalian liver. |
| Volume | 262 |
| Pages | 10-14 |
| Published | 2019-3-1 |
| DOI | 10.1016/j.virusres.2018.04.015 |
| PII | S0168-1702(18)30160-6 |
| PMID | 29702129 |
| MeSH | Animals Asia Cell Line DNA-Binding Proteins / genetics Dependovirus / genetics* Elephants / genetics Elephants / virology* Evolution, Molecular Genome* Liver / virology Open Reading Frames / genetics Phylogeny Viral Proteins / genetics* Virus Integration* |
| IF | 2.736 |
| Times Cited | 2 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 5 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | LACF-NaNaII(RCB2320) |