| RRC ID |
6001
|
| Author |
Ju SY, Cho KA, Cho SJ, Jung YJ, Woo SY, Seoh JY, Han HS, Ryu KH.
|
| Title |
Effect of hypoxic treatment on bone marrow cells that are able to migrate to the injured liver.
|
| Journal |
Cell Biol Int
|
| Abstract |
Restricted numbers and poor regenerative properties limit the use of adult stem cells. We tested the effect of hypoxic treatment as a method by which to increase cell migration. Bone marrow cells (BMCs) were cultured under oxygen saturations of 0.1, 3, and 20% for 24h. After hypoxic treatment, BMCs of apoptotic fraction were decreased. The expression of CXCR4 was noticeably increased in the hypoxia-treated BMCs and their migration in response to SDF-1alpha was enhanced compared with cells cultured under normoxic condition. Hypoxic BMCs had a higher degree of engraftment to the CCl(4)-injured liver than the normoxic cells. Hypoxic treatment of BMCs may have merits in decreasing apoptosis of those cells as well as in enhancing cellular migration to SDF-1alpha, the chemokine which binds to BMCs expressed CXCR4 and to the injured tissue, such as CCl(4) damaged liver.
|
| Volume |
33(1)
|
| Pages |
31-5
|
| Published |
2009-1-1
|
| DOI |
10.1016/j.cellbi.2008.10.002
|
| PII |
S1065-6995(08)00593-3
|
| PMID |
18992833
|
| MeSH |
Animals
Apoptosis
Bone Marrow Cells / drug effects
Bone Marrow Cells / physiology*
Bone Marrow Transplantation
Carbon Tetrachloride Poisoning / metabolism
Cell Hypoxia
Cell Movement / physiology*
Chemokine CXCL12 / metabolism
Female
Flow Cytometry
Liver / drug effects*
Liver / enzymology
Mice
Mice, Inbred C57BL
Mice, Transgenic
Receptors, CXCR4 / drug effects
Receptors, CXCR4 / metabolism
|
| IF |
2.571
|
| Times Cited |
5
|
|
WOS Category
|
CELL BIOLOGY
|
| Resource |
| Mice |
RBRC00267 |
