RRC ID 60047
Author Cau E, Ronsin B, Bessière L, Blader P.
Title A Notch-mediated, temporal asymmetry in BMP pathway activation promotes photoreceptor subtype diversification.
Journal PLoS Biol
Abstract Neural progenitors produce neurons whose identities can vary as a function of the time that specification occurs. Here, we describe the heterochronic specification of two photoreceptor (PhR) subtypes in the zebrafish pineal gland. We find that accelerating PhR specification by impairing Notch signaling favors the early fate at the expense of the later fate. Using in vivo lineage tracing, we show that most pineal PhRs are born from a fate-restricted progenitor. Furthermore, sister cells derived from the division of PhR-restricted progenitors activate the bone morphogenetic protein (BMP) signaling pathway at different times after division, and this heterochrony requires Notch activity. Finally, we demonstrate that PhR identity is established as a function of when the BMP pathway is activated. We propose a novel model in which division of a progenitor with restricted potential generates sister cells with distinct identities via a temporal asymmetry in the activation of a signaling pathway.
Volume 17(1)
Pages e2006250
Published 2019-1
DOI 10.1371/journal.pbio.2006250
PII pbio.2006250
PMID 30703098
PMC PMC6372210
MeSH Animals Bone Morphogenetic Proteins / metabolism Cell Differentiation / genetics Cell Lineage Embryo, Nonmammalian / metabolism Gene Expression Regulation, Developmental / genetics Neurons / metabolism Photoreceptor Cells, Vertebrate / physiology* Pineal Gland / embryology* Pineal Gland / metabolism Pineal Gland / physiology Receptors, Notch / metabolism* Signal Transduction Time Factors Zebrafish / genetics Zebrafish / metabolism Zebrafish Proteins / metabolism
IF 8.386
Times Cited 2
Resource
Zebrafish Tg(exorh:EGFP)ja1