| RRC ID |
60047
|
| 著者 |
Cau E, Ronsin B, Bessière L, Blader P.
|
| タイトル |
A Notch-mediated, temporal asymmetry in BMP pathway activation promotes photoreceptor subtype diversification.
|
| ジャーナル |
PLoS Biol
|
| Abstract |
Neural progenitors produce neurons whose identities can vary as a function of the time that specification occurs. Here, we describe the heterochronic specification of two photoreceptor (PhR) subtypes in the zebrafish pineal gland. We find that accelerating PhR specification by impairing Notch signaling favors the early fate at the expense of the later fate. Using in vivo lineage tracing, we show that most pineal PhRs are born from a fate-restricted progenitor. Furthermore, sister cells derived from the division of PhR-restricted progenitors activate the bone morphogenetic protein (BMP) signaling pathway at different times after division, and this heterochrony requires Notch activity. Finally, we demonstrate that PhR identity is established as a function of when the BMP pathway is activated. We propose a novel model in which division of a progenitor with restricted potential generates sister cells with distinct identities via a temporal asymmetry in the activation of a signaling pathway.
|
| 巻・号 |
17(1)
|
| ページ |
e2006250
|
| 公開日 |
2019-1-1
|
| DOI |
10.1371/journal.pbio.2006250
|
| PII |
pbio.2006250
|
| PMID |
30703098
|
| PMC |
PMC6372210
|
| MeSH |
Animals
Bone Morphogenetic Proteins / metabolism
Cell Differentiation / genetics
Cell Lineage
Embryo, Nonmammalian / metabolism
Gene Expression Regulation, Developmental / genetics
Neurons / metabolism
Photoreceptor Cells, Vertebrate / physiology*
Pineal Gland / embryology*
Pineal Gland / metabolism
Pineal Gland / physiology
Receptors, Notch / metabolism*
Signal Transduction
Time Factors
Zebrafish / genetics
Zebrafish / metabolism
Zebrafish Proteins / metabolism
|
| IF |
8.386
|
| 引用数 |
2
|
| リソース情報 |
| ゼブラフィッシュ |
Tg(exorh:EGFP)ja1 |
