論文 - 詳細
| RRC ID | 60050 |
|---|---|
| 著者 | Mano H, Asaoka Y, Kojima D, Fukada Y. |
| タイトル | Brain-specific homeobox Bsx specifies identity of pineal gland between serially homologous photoreceptive organs in zebrafish. |
| ジャーナル | Commun Biol |
| Abstract |
The pineal gland functioning as a photoreceptive organ in non-mammalian species is a serial homolog of the retina. Here we found that Brain-specific homeobox (Bsx) is a key regulator conferring individuality on the pineal gland between the two serially homologous photoreceptive organs in zebrafish. Bsx knock-down impaired the pineal development with reduced expression of exorh, the pineal-specific gene responsible for the photoreception, whereas it induced ectopic expression of rho, a retina-specific gene, in the pineal gland. Bsx remarkably transactivated the exorh promoter in combination with Otx5, but not with Crx, through its binding to distinct subtypes of PIRE, a DNA cis-element driving Crx/Otx-dependent pineal-specific gene expression. These results demonstrate that the identity of pineal photoreceptive neurons is determined by the combinatorial code of Bsx and Otx5, the former confers the pineal specificity at the tissue level and the latter determines the photoreceptor specificity at the cellular level. |
| 巻・号 | 2 |
| ページ | 364 |
| 公開日 | 2019-1-1 |
| DOI | 10.1038/s42003-019-0613-1 |
| PII | 613 |
| PMID | 31602413 |
| PMC | PMC6779754 |
| MeSH | Animals Animals, Genetically Modified Gene Expression Regulation, Developmental Homeodomain Proteins / genetics Homeodomain Proteins / metabolism* Otx Transcription Factors / metabolism PAX6 Transcription Factor / metabolism Pineal Gland / cytology Pineal Gland / growth & development Pineal Gland / metabolism* Promoter Regions, Genetic Rhodopsin / metabolism Trans-Activators / metabolism Transcription Factors / metabolism Zebrafish Zebrafish Proteins / genetics Zebrafish Proteins / metabolism* |
| IF | 4.165 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | RIKEN WT Tg(exorh:egfp) |