論文 - 詳細
| RRC ID | 60051 |
|---|---|
| 著者 | Satria D, Amen Y, Niwa Y, Ashour A, Allam AE, Shimizu K. |
| タイトル | Lucidumol D, a new lanostane-type triterpene from fruiting bodies of Reishi (Ganoderma lingzhi). |
| ジャーナル | Nat Prod Res |
| Abstract |
A new lanostane-type triterpenoid, lucidumol D (1) was isolated from the fruiting bodies of Ganoderma lingzhi. Its structure was elucidated on the basis of extensive 1D- and 2D-NMR studies as well as mass spectrometry. The cytotoxicity of lucidumol D against proliferation of several cancer cells were assayed by using MTT method and the obtained result suggested selective anti-proliferative and cytotoxic effects against MCF-7, HepG2, HeLa, Caco-2, and HCT-116. In comparison to lucidumol C (2) isolated previously by our group, the structure-activity relationship indicated that carbonyl function at C-11 is necessary to enhance the cytotoxicity. |
| 巻・号 | 33(2) |
| ページ | 189-195 |
| 公開日 | 2019-1-1 |
| DOI | 10.1080/14786419.2018.1440229 |
| PMID | 29457741 |
| MeSH | Antineoplastic Agents / chemistry* Antineoplastic Agents / pharmacology* Cell Line, Tumor Cell Proliferation / drug effects Drug Screening Assays, Antitumor Fruiting Bodies, Fungal / chemistry Ganoderma / chemistry* Humans Magnetic Resonance Spectroscopy Molecular Structure Structure-Activity Relationship Triterpenes / chemistry* Triterpenes / pharmacology* |
| IF | 1.999 |
| 引用数 | 6 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Google+ |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | MCF7(RCB1904) Hep G2(RCB1886) HeLa(RCB0007) CACO-2(RCB0988) HCT116(RCB2979) |