RRC ID 60051
Author Satria D, Amen Y, Niwa Y, Ashour A, Allam AE, Shimizu K.
Title Lucidumol D, a new lanostane-type triterpene from fruiting bodies of Reishi (Ganoderma lingzhi).
Journal Nat Prod Res
Abstract A new lanostane-type triterpenoid, lucidumol D (1) was isolated from the fruiting bodies of Ganoderma lingzhi. Its structure was elucidated on the basis of extensive 1D- and 2D-NMR studies as well as mass spectrometry. The cytotoxicity of lucidumol D against proliferation of several cancer cells were assayed by using MTT method and the obtained result suggested selective anti-proliferative and cytotoxic effects against MCF-7, HepG2, HeLa, Caco-2, and HCT-116. In comparison to lucidumol C (2) isolated previously by our group, the structure-activity relationship indicated that carbonyl function at C-11 is necessary to enhance the cytotoxicity.
Volume 33(2)
Pages 189-195
Published 2019-1-1
DOI 10.1080/14786419.2018.1440229
PMID 29457741
IF 1.999
Resource
Human and Animal Cells MCF7(RCB1904) Hep G2(RCB1886) HeLa(RCB0007) CACO-2(RCB0988) HCT116(RCB2979)