Reference - Detail
| RRC ID | 60051 |
|---|---|
| Author | Satria D, Amen Y, Niwa Y, Ashour A, Allam AE, Shimizu K. |
| Title | Lucidumol D, a new lanostane-type triterpene from fruiting bodies of Reishi (Ganoderma lingzhi). |
| Journal | Nat Prod Res |
| Abstract |
A new lanostane-type triterpenoid, lucidumol D (1) was isolated from the fruiting bodies of Ganoderma lingzhi. Its structure was elucidated on the basis of extensive 1D- and 2D-NMR studies as well as mass spectrometry. The cytotoxicity of lucidumol D against proliferation of several cancer cells were assayed by using MTT method and the obtained result suggested selective anti-proliferative and cytotoxic effects against MCF-7, HepG2, HeLa, Caco-2, and HCT-116. In comparison to lucidumol C (2) isolated previously by our group, the structure-activity relationship indicated that carbonyl function at C-11 is necessary to enhance the cytotoxicity. |
| Volume | 33(2) |
| Pages | 189-195 |
| Published | 2019-1-1 |
| DOI | 10.1080/14786419.2018.1440229 |
| PMID | 29457741 |
| MeSH | Antineoplastic Agents / chemistry* Antineoplastic Agents / pharmacology* Cell Line, Tumor Cell Proliferation / drug effects Drug Screening Assays, Antitumor Fruiting Bodies, Fungal / chemistry Ganoderma / chemistry* Humans Magnetic Resonance Spectroscopy Molecular Structure Structure-Activity Relationship Triterpenes / chemistry* Triterpenes / pharmacology* |
| IF | 1.999 |
| Times Cited | 6 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Google+ |
| Total number of mentions | 3 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | MCF7(RCB1904) Hep G2(RCB1886) HeLa(RCB0007) CACO-2(RCB0988) HCT116(RCB2979) |