| RRC ID |
60051
|
| 著者 |
Satria D, Amen Y, Niwa Y, Ashour A, Allam AE, Shimizu K.
|
| タイトル |
Lucidumol D, a new lanostane-type triterpene from fruiting bodies of Reishi (Ganoderma lingzhi).
|
| ジャーナル |
Nat Prod Res
|
| Abstract |
A new lanostane-type triterpenoid, lucidumol D (1) was isolated from the fruiting bodies of Ganoderma lingzhi. Its structure was elucidated on the basis of extensive 1D- and 2D-NMR studies as well as mass spectrometry. The cytotoxicity of lucidumol D against proliferation of several cancer cells were assayed by using MTT method and the obtained result suggested selective anti-proliferative and cytotoxic effects against MCF-7, HepG2, HeLa, Caco-2, and HCT-116. In comparison to lucidumol C (2) isolated previously by our group, the structure-activity relationship indicated that carbonyl function at C-11 is necessary to enhance the cytotoxicity.
|
| 巻・号 |
33(2)
|
| ページ |
189-195
|
| 公開日 |
2019-1-1
|
| DOI |
10.1080/14786419.2018.1440229
|
| PMID |
29457741
|
| MeSH |
Antineoplastic Agents / chemistry*
Antineoplastic Agents / pharmacology*
Cell Line, Tumor
Cell Proliferation / drug effects
Drug Screening Assays, Antitumor
Fruiting Bodies, Fungal / chemistry
Ganoderma / chemistry*
Humans
Magnetic Resonance Spectroscopy
Molecular Structure
Structure-Activity Relationship
Triterpenes / chemistry*
Triterpenes / pharmacology*
|
| IF |
1.999
|
| 引用数 |
6
|
| リソース情報 |
| ヒト・動物細胞 |
MCF7(RCB1904)
Hep G2(RCB1886)
HeLa(RCB0007)
CACO-2(RCB0988)
HCT116(RCB2979) |
